Protein Info for SM_b21287 in Sinorhizobium meliloti 1021

Annotation: xanthine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 14 to 772 (759 residues), 1397.1 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 28 to 136 (109 residues), 109.7 bits, E=1.5e-35
• PF02738: MoCoBD_1
  • amino acids 157 to 389 (233 residues), 288.9 bits, E=3.6e-90
• PF20256: MoCoBD_2
  • amino acids 417 to 700 (284 residues), 337.6 bits, E=1.1e-104

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 100% identity to sme:SM_b21287)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (11/11 steps found)
• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• inosine 5'-phosphate degradation (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• ureide biosynthesis (6/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (2/7 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (2/10 steps found)
• theophylline degradation (1/9 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See Q92VB7 at UniProt or InterPro

Protein Sequence (777 amino acids)

>SM_b21287 xanthine dehydrogenase (Sinorhizobium meliloti 1021)
MNVMQPVDRVRGAVHDKERHESGHKHVSGTAEYIDDIPEPAGTLHGYLGLSQRAHAEILS
VDFEAVRNSPGVVGVLTAEDIPGENDISPAHKHDDPVFAAGKVEFHGQPIFAVIATSREA
ARRAAAKVKIDYRDLPHVTDVLEAAAANYPLVIDPLKLERGDIDAGFAKAKNTVSGEMRI
GGQDHFYLEGQISFAIPGEDDEVTVFSSTQHPSETQLMVAHVLGVPSNAVTVNIRRMGGG
FGGKETQANLFAAVAAVAARKYRRAIKVRPDRDDDMTATGKRHDFHVDYKVGFDDDGRIE
AVDAVFAARCGFSADLSGPVTDRALFHADNCYFYPNVRLRSRPLKTNTVSNTAFRGFGGP
QGMVGGERMVEDVAYALGKDPLEIRKLNFYGGEGRNLTPYHQTVEDNIIGRIIEELEVSS
DYAARRQAAIAFNRESPVIKRGIALTPVKFGISFTKTEYNQAGALVHVYTDGSIQLNHGG
TEMGQGLYTKVAQVVADEFQVDLDHIKVTATSTGKVPNTSATAASSGSDLNGMAAANACQ
QIKERLVRFAAERYGVGEADIAFEPNTVRIGAERIAFADLIKAAYAARVQLSAAGFYKTP
KIHWSRAEGRGRPFYYFAYGASCSEVSVDTLTGEYQVERTDIIHDVGKSLNPALDLGQVE
GAFVQGMGWLTTEELWWDAKGRLRTHAPSTYKIPLASDRPRVFNVRLAEWSINREETIRR
SKAVGEPPFMLGISVLEAISMAAASVADYRIPPRIDAPATPERVLMAVERLRAARAG