Protein Info for SM_b21152 in Sinorhizobium meliloti 1021

Annotation: sugar uptake ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 PF00005: ABC_tran" amino acids 19 to 161 (143 residues), 121.3 bits, see alignment E=7.3e-39 PF17912: OB_MalK" amino acids 235 to 287 (53 residues), 33.4 bits, see alignment 1e-11 PF08402: TOBE_2" amino acids 280 to 351 (72 residues), 33.8 bits, see alignment E=4.5e-12

Best Hits

Swiss-Prot: 50% identical to MALK_PHOLL: Maltose/maltodextrin import ATP-binding protein MalK (malK) from Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

KEGG orthology group: K02023, multiple sugar transport system ATP-binding protein (inferred from 100% identity to sme:SM_b21152)

Predicted SEED Role

"Maltose/maltodextrin transport ATP-binding protein MalK (EC 3.6.3.19)" in subsystem Maltose and Maltodextrin Utilization (EC 3.6.3.19)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.19

Use Curated BLAST to search for 3.6.3.19

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92V91 at UniProt or InterPro

Protein Sequence (377 amino acids)

>SM_b21152 sugar uptake ABC transporter ATP-binding protein (Sinorhizobium meliloti 1021)
MGQLTLNKVQKFYGTYEVLKSIELEVGNGEFVVFVGPSGCGKSTLLRMIAGLDETTAGDI
VIDGKRVNDLPPVRRGIAMVFQSYALYPHMSVFENIAFPLRVEKMPEEKLKAKVEHAARI
LHLDQRLEQKPGMLSGGQRQRVAIGRAIVREPKIFLFDEPLSNLDAALRADMRIELAKLH
RQLKATMIYVTHDQVEAMTMADRIVVLNAGEIAQTGAPLELYHKPANIFVAGFIGHPKMN
FLPVACTGVTDAGVEVDYKGQTILVPVVPRAGMASRTLTLGVRPEHIQMGAADLTLTVTP
SVIERLGAHTVAYVALDGEGENYCAMLPGTLAIRADEPIRTGIRAVDCHLFDENGTAFER
RVEMTDIDMALFDPAAA