Protein Info for SM_b21151 in Sinorhizobium meliloti 1021

Annotation: substrate-binding protein of a sugar uptake ABC transporter system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 409 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF01547: SBP_bac_1" amino acids 46 to 324 (279 residues), 129.7 bits, see alignment E=2.5e-41 PF13416: SBP_bac_8" amino acids 47 to 352 (306 residues), 124.2 bits, see alignment E=8.9e-40

Best Hits

KEGG orthology group: K02027, multiple sugar transport system substrate-binding protein (inferred from 100% identity to sme:SM_b21151)

Predicted SEED Role

"Inositol transport system sugar-binding protein" in subsystem Inositol catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92V92 at UniProt or InterPro

Protein Sequence (409 amino acids)

>SM_b21151 substrate-binding protein of a sugar uptake ABC transporter system (Sinorhizobium meliloti 1021)
MTIAYKATFLTLALLGSTALGSVAAQAADQEISWIYCGDTIDPIHEKYIKEWEGKNPGWK
VTPEVVGWAQCQDKATTLAVAGTPVGMAYVGSRALKEFAENELIVPVPMTEDEKKGYYPN
IVDTVTFEGTQWGVPIAFSTKALYWNKDLFKQAGLDPEVPPKTWAEEIAFAKQIKEKTGI
AGYGLPAKTFDNTMHQFMHWVYTNNGKVIDGDNIVIDSPEVLAALQAYKDITPFSVEGAT
AYEQNEIRAIFLDGKVGMIQSGSGAAARLKETKVNWGVAPLPLGPSAKGDGTLLITDSLV
VFKDTGVEEKAIEFAKFITSPGPQGEYELQGGAGLTPLRPSPKVDEFVKADPSWKPFIDG
IAYGGPEPLFKDFKGFQNTMIEMVQSVVTGKAEPADALKKAAADLEQYK