Protein Info for SM_b21016 in Sinorhizobium meliloti 1021

Annotation: sugar ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 343 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF13407: Peripla_BP_4" amino acids 32 to 288 (257 residues), 213.5 bits, see alignment E=2e-67

Best Hits

Swiss-Prot: 76% identical to LSRB_ECOLC: Autoinducer 2-binding protein LsrB (lsrB) from Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

KEGG orthology group: K10555, AI-2 transport system substrate-binding protein (inferred from 100% identity to smk:Sinme_5083)

MetaCyc: 76% identical to Autoinducer-2 ABC transporter periplasmic binding protein (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-454 [EC: 7.6.2.13]

Predicted SEED Role

"Autoinducer 2 (AI-2) ABC transport system, periplasmic AI-2 binding protein LsrB" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q926H7 at UniProt or InterPro

Protein Sequence (343 amino acids)

>SM_b21016 sugar ABC transporter substrate-binding protein (Sinorhizobium meliloti 1021)
MIKTIMKSSALAAALLAGTVLASGAAHAENQIAFIPKLVGVGFFTSGGAGAVKAGEEVGA
KVTYDGPTEPSVSGQVQFINNFVNQGYNALIVSSVSPDGLCPALKRAMERGVLVMTWDSD
VNPDCRSYYINQGTPEQLGGLLVDMAAEGVKKEKAKVAFFYSSPTVTDQNAWAEAAKAKI
AKEHPGWEIVTTQYGYNDAQKSLQTAESILQTYPDLDAIIAPDANALPAAAQAAENLKRA
EGVTIVGFSTPNVMRPYIERGTIQRFGLWDVTQQGKISVFVADHVLKNGPMKVGEKLEIP
GVGTVEVSANKVQGYDYEADGNGIILLPERTVFTKENIGNFDF