Protein Info for SM_b21002 in Sinorhizobium meliloti 1021
Annotation: methionine aminopeptidase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 45% identical to MAP1_STAAM: Methionine aminopeptidase (map) from Staphylococcus aureus (strain Mu50 / ATCC 700699)
KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 100% identity to sme:SM_b21002)Predicted SEED Role
"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)
MetaCyc Pathways
- Arg/N-end rule pathway (eukaryotic) (8/14 steps found)
- Ac/N-end rule pathway (6/21 steps found)
Isozymes
Compare fitness of predicted isozymes for: 3.4.11.18
Use Curated BLAST to search for 3.4.11.18
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92UK0 at UniProt or InterPro
Protein Sequence (249 amino acids)
>SM_b21002 methionine aminopeptidase (Sinorhizobium meliloti 1021) MTLNNDEDLERLKEIGRICANALQAMGEALELGITTAELDAIGRKVLEDAGARSAPELCY DFPGATCISVNEEIAHGIPGRRVIQPGDLVNIDVSAEKGGLFADTGASFPVPPVKTEIDR LCRDGKRAMWVGLKQVKPGQSLAAIGNSIGEFARKNRYSLVANLASHGIGRSLHEEPSEI ATWPDPSERRRMTEGMVFTVEPFLSMGAQWAEGGDDDWTLYSEPRAPTVQYEHTVVVTRS GPLVVTLPG