Protein Info for SM_b20979 in Sinorhizobium meliloti 1021

Annotation: large C4-dicarboxylate uptake permease, DedA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 transmembrane" amino acids 12 to 37 (26 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 138 to 164 (27 residues), see Phobius details amino acids 174 to 197 (24 residues), see Phobius details amino acids 218 to 240 (23 residues), see Phobius details amino acids 246 to 262 (17 residues), see Phobius details amino acids 282 to 300 (19 residues), see Phobius details amino acids 320 to 349 (30 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details amino acids 402 to 425 (24 residues), see Phobius details PF06808: DctM" amino acids 12 to 422 (411 residues), 340.2 bits, see alignment E=8.5e-106 TIGR00786: TRAP transporter, DctM subunit" amino acids 21 to 427 (407 residues), 390.1 bits, see alignment E=5.1e-121

Best Hits

Swiss-Prot: 41% identical to SIAM_VIBCH: Sialic acid TRAP transporter large permease protein SiaM (siaM) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20979)

MetaCyc: 37% identical to 2,3-diketo-L-gulonate:Na+ symporter - membrane subunit (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-235

Predicted SEED Role

"TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UM2 at UniProt or InterPro

Protein Sequence (437 amino acids)

>SM_b20979 large C4-dicarboxylate uptake permease, DedA family protein (Sinorhizobium meliloti 1021)
MTLFHLAGPSLLVVVLFLLSTPITWAMAIGAFAFFLINMDMIPLANFAQEMAEGSQSVSL
LALPLFVLAGCIMNASGITRRLLALADVLVGHMTGALAQMCTVLGTLLGGLTASANADAA
MLAKTLGVEMSQRGYSRAFAAVITSSAAIITSLIPPSIGLIVYGFLAETSIGRLFAAGVI
PGLVLATGLMVTTYFIARKRGYKPLRKERATRAEGVRALIDGLWALSIPVVIFAGTRYGL
FTTTEAGAVVVVYVLFVAVFGYREFTFRQIPEVLAEAVRDSAVVMIMICAAAAFGFYLAW
EQVPQAMSGWLGEATDNPLLMLLLINVLLIVIGTAIEGSAALIILTPMLIPIIDGVGIDR
VHFGVVFITNLTIAGITPPVGGLMYISSMVLKVPMMAYAREVLPYLAMMMVILVMLSMFP
QLSLWLPNLVYGTTAVQ