Protein Info for SM_b20933 in Sinorhizobium meliloti 1021

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 907 PF00989: PAS" amino acids 22 to 59 (38 residues), 24.7 bits, see alignment (E = 1.1e-08) amino acids 150 to 259 (110 residues), 77.8 bits, see alignment E=3.7e-25 TIGR00229: PAS domain S-box protein" amino acids 23 to 145 (123 residues), 25.9 bits, see alignment E=4.6e-10 amino acids 145 to 269 (125 residues), 107.2 bits, see alignment E=3.2e-35 amino acids 525 to 584 (60 residues), 30.4 bits, see alignment 1.8e-11 amino acids 639 to 710 (72 residues), 25.6 bits, see alignment E=5.6e-10 PF08448: PAS_4" amino acids 27 to 138 (112 residues), 25.3 bits, see alignment E=8.6e-09 amino acids 154 to 263 (110 residues), 50.3 bits, see alignment E=1.4e-16 amino acids 461 to 578 (118 residues), 41.7 bits, see alignment E=6.8e-14 PF13426: PAS_9" amino acids 37 to 138 (102 residues), 34.5 bits, see alignment E=1.2e-11 amino acids 159 to 261 (103 residues), 61.7 bits, see alignment E=4e-20 PF13188: PAS_8" amino acids 149 to 201 (53 residues), 28.1 bits, see alignment 8.1e-10 PF08447: PAS_3" amino acids 171 to 253 (83 residues), 29.6 bits, see alignment E=3.7e-10 amino acids 612 to 697 (86 residues), 46.6 bits, see alignment E=1.9e-15 PF13185: GAF_2" amino acids 291 to 426 (136 residues), 45.2 bits, see alignment E=6.4e-15 PF13492: GAF_3" amino acids 292 to 427 (136 residues), 27.7 bits, see alignment E=1.8e-09 PF01590: GAF" amino acids 292 to 425 (134 residues), 42.9 bits, see alignment E=3.9e-14 PF07568: HisKA_2" amino acids 717 to 776 (60 residues), 32.2 bits, see alignment 5e-11 PF07536: HWE_HK" amino acids 717 to 798 (82 residues), 93.5 bits, see alignment E=6.2e-30

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20933)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UP1 at UniProt or InterPro

Protein Sequence (907 amino acids)

>SM_b20933 two-component sensor histidine kinase (Sinorhizobium meliloti 1021)
MHGAEILPKTTIDDVTTSDTPDYRAVLDALAVPVYATDAEGIVTYCNAAAAAVAGREPEL
GKDRWCVSWQLRRPDGSPLPHDECPMARTLKEGQPVRGEEVVAVRPDGASVPLLPHPTPI
FDDTGALTGAVNVLMDLSGAKDMERSSRYLAAIVESSDDAIVAKNLDGIITSWNRGAQRL
FGYAAEEVIGESITILIPPERLSEEPGILERIRRGELVDHFETKRRRKDGTLVDISLTVS
PVRDATGRIIGASKIARDITETKSAAEALAARFREQAALYRLTERVQRTKRIEEVYEATL
DAIQGALNCDRASILLFDEAGTMRFVAARGLSEHYQRAVDGHSPWITGANEPEPIFVENV
DDAEFSRELKESIVGEGIAALGFFPLVTEGRLIGKFMTYYDRPHRFADSEIGMALTIARQ
LGFSIQRMRAEYARRQAEEQLRRNEANERARAAELAAIMEAVPALIWIARTPDCRVISGN
NSSYEILRLPHDSNLSMSAPPGEHPTNFRVFSEGRALSPEELPVQRAARGEEVQNFEEEV
RFDDGSSRHIFGNATPLRDVTGEVVGAVAAAVDITGRKQAEEALQESERRLQLALDAGHM
GAWEWNLETGEVIWSPGLEALHRIEPGSFGGTLADFKRDIHPDDLPLIEREMARAIETDG
DYHVVYRAQLPDGTIRWMEAFGQLSPRNGPKRRLTGVCMDITERREAEAQRNLLVAELSH
RVKNTLAIVGSIARQTFSTNPDAKAAHRSFDARIRALAQTHTRLAEASWSGVSLKTVLFD
ELSPYHDDSRTNVTLAGPPAMLPPKHALTLGMAAHELATNAAKHGALSVRSGKVDIEWMI
DVASERLRICWSETGGPAVVAPKHNGFGRLLLERVLASDLGGEVHLEFAPQGLVCTIDVP
YPRGAPG