Protein Info for SM_b20894 in Sinorhizobium meliloti 1021

Updated annotation (from data): L-arabinose ABC transporter, ATPase component
Rationale: Specific phenotype: utilization of L-Arabinose. 79% identical to Atu2347 (GguA) from Agrobacterium, which also transports fucose, galactose, xylose, and glucose, so this may have a broader substrate range.
Original annotation: sugar uptake ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF00005: ABC_tran" amino acids 31 to 167 (137 residues), 63.1 bits, see alignment E=2.2e-21 amino acids 275 to 431 (157 residues), 66.7 bits, see alignment E=1.7e-22

Best Hits

Swiss-Prot: 62% identical to ARAG_GEOSE: L-arabinose transport ATP-binding protein AraG (araG) from Geobacillus stearothermophilus

KEGG orthology group: K10548, putative multiple sugar transport system ATP-binding protein (inferred from 100% identity to sme:SM_b20894)

Predicted SEED Role

"ABC transporter ATP-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UE3 at UniProt or InterPro

Protein Sequence (506 amino acids)

>SM_b20894 L-arabinose ABC transporter, ATPase component (Sinorhizobium meliloti 1021)
MKCGALRRRFRASRPWTMSRSRSAKARSTRLSGKTAPAKSTLMKVLSGVYPAGTYEGEIH
YDGELRQFSTISDSEELGIIIIHQELALVPLLSIAENIFLGNEVAEKGVIHWPQTFARTQ
ELLKKVGLNESPATLITDIGVGKQQLVEIAKALSKKVRLLILDEPTASLNENDSDALLKL
LMEFRSQGMTSIIISHKLNEIKKVADQITILRDGGTVETLDCHKEDISEDRIINGMVGRA
MEDRYPPREPKIGDTLLEVKNWNVYHQHHRDRQFLHDVSFKVRAGEVVGIAGLMGAGRTE
TAMSVFGKSWGHKITGEVTMHGRPVDVSTIPKAIKAGLAYVTEDRKQLGLVLINNIMHNT
TLANLHAVASNGVIDERKERKVAAEYRSKLRIRSHSIYQETVNLSGGNQQKVVLSKWLFT
NPEVLILDEPTRGIDIGAKYEIYTIINQLAAEGKGILMISSEMPELLGTCDRIYVMNEGR
MVAELSKEEASQESIMRAIMRSGEKH