Protein Info for SM_b20873 in Sinorhizobium meliloti 1021

Annotation: ureidoglycolate hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to ALLA1_RHIME: Ureidoglycolate lyase 1 (allA1) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01483, ureidoglycolate hydrolase [EC: 3.5.3.19] (inferred from 100% identity to sme:SM_b20873)

Predicted SEED Role

"Ureidoglycolate hydrolase (EC 3.5.3.19)" in subsystem Allantoin Utilization (EC 3.5.3.19)

MetaCyc Pathways

allantoin degradation to glyoxylate II (2/5 steps found)
superpathway of allantoin degradation in plants (4/8 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.3.19

Use Curated BLAST to search for 3.5.3.19

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UG4 at UniProt or InterPro

Protein Sequence (170 amino acids)

>SM_b20873 ureidoglycolate hydrolase (Sinorhizobium meliloti 1021)
MSHMLSIEPLTREAFAPFGSVIEADPASMRFINGGNTERFHALARVDAAGEGAGVIINIF
RGQPRVFPYSVTMMERHPLGSQSFSPLRDRPWLVVVAEDQGDRPGRPRVFIADGRQGVNY
GRNVWHHPLMSVGAVSEFIVVDREGPGNNLEEFHYDEAFVIPDPSSEELR