Protein Info for SM_b20868 in Sinorhizobium meliloti 1021

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1229 signal peptide" amino acids 12 to 13 (2 residues), see Phobius details transmembrane" amino acids 14 to 31 (18 residues), see Phobius details amino acids 39 to 55 (17 residues), see Phobius details amino acids 62 to 80 (19 residues), see Phobius details amino acids 86 to 108 (23 residues), see Phobius details amino acids 120 to 147 (28 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 196 to 221 (26 residues), see Phobius details amino acids 236 to 259 (24 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details PF05231: MASE1" amino acids 14 to 294 (281 residues), 242 bits, see alignment E=3.8e-75 TIGR00229: PAS domain S-box protein" amino acids 309 to 441 (133 residues), 52.5 bits, see alignment E=2.6e-18 amino acids 602 to 730 (129 residues), 27 bits, see alignment E=2e-10 amino acids 732 to 858 (127 residues), 32.2 bits, see alignment E=5.2e-12 amino acids 859 to 991 (133 residues), 50.5 bits, see alignment E=1.1e-17 PF00989: PAS" amino acids 314 to 431 (118 residues), 24.1 bits, see alignment E=1.4e-08 amino acids 736 to 844 (109 residues), 23.9 bits, see alignment E=1.6e-08 amino acids 867 to 981 (115 residues), 26.6 bits, see alignment E=2.3e-09 PF08448: PAS_4" amino acids 323 to 435 (113 residues), 30.7 bits, see alignment E=1.4e-10 amino acids 742 to 851 (110 residues), 25.5 bits, see alignment E=5.8e-09 amino acids 870 to 984 (115 residues), 33 bits, see alignment E=2.7e-11 PF13426: PAS_9" amino acids 330 to 431 (102 residues), 32.5 bits, see alignment E=4e-11 amino acids 880 to 981 (102 residues), 26.5 bits, see alignment E=2.9e-09 PF08447: PAS_3" amino acids 337 to 424 (88 residues), 60.7 bits, see alignment 6e-20 amino acids 656 to 715 (60 residues), 52.6 bits, see alignment 2e-17 amino acids 758 to 841 (84 residues), 42.5 bits, see alignment 3e-14 amino acids 886 to 976 (91 residues), 62.3 bits, see alignment 2e-20 PF02518: HATPase_c" amino acids 1119 to 1223 (105 residues), 76.9 bits, see alignment E=7.3e-25 PF14501: HATPase_c_5" amino acids 1121 to 1211 (91 residues), 30.3 bits, see alignment 1.5e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20868)

Predicted SEED Role

"putative repetitive two-component sensor histidine kinase transcriptional regulatory protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UG9 at UniProt or InterPro

Protein Sequence (1229 amino acids)

>SM_b20868 two-component sensor histidine kinase (Sinorhizobium meliloti 1021)
MMLIWPYRPHPRHLALFIVAYVLGCGFAHALAIVPGTGISFWAPSGLFIATLALVQRQSW
PWWLLAGCFAEVLSNFLWFHSPFPAAMLIYVGNALEAVIGASLVNWALKRSIRLETLREV
LAFVVLGAGVAPVVSATVGSATLAWFGILSQTFTGAWPLWWIGDATGVLIVAPLAFIVIQ
NWRDKTELSAARLAEACVLGLIFLGVAALSLSGYLPFAYIIMPPLLWAAVRFEVKGAVVV
LVLLTLITAIFTISGTSPFAGDHETQRHKQFMLQLFLAISAFSALIVAAISRQYQLALSN
LQQSVATLRERERELSQIVNMVPVHIRRLTPEGEPTFFNKRLTDFFGLDLQQLEKPNASR
LVTAVQTLVHPDDADSLLQAVRRSLATGEPYSIKYRMRRADGAYRWVDGRAEPLRDDSGT
ILQWFAISIDIDDEVRMQEALKQSERRYRELFHYMPIGLAQIDAGKLIPMFKEMRAQGVV
SLETYMDENPEFLSHALEALEVEEVNQHVIDMFRANSREEMGGSITRYWQPALATIRRSI
EARYRGEEVFQEETRVARMDGSVMDVVFAIAQPGAIADKSLVGFIDITERKRAEEALRAR
EREFSQLVNMVPSYLWRLTPDGVPNFLNQRLIDFLGPDVVNANVEGVHPLAAIIGAVVHP
DDKTRMSNALFHSVATGERFSMKYRLRRADGVYRWVEGSAEPMRDEEGRILQWYGLSHDI
DDIMHVEEALRNSKQQLEQMIEAVPFSTLSFAPTGELTYVSKRYQDQAGAPGAEIKDFDA
LAREVAHPDDFPTMFARATQGFATGQPFVNRFRRRLKDGNYRWIEARAQPLRRADGPIVQ
WYFASIDIEEEMRAQEALRERERFLWQLVETLPAMIDCAAPNGEPVYRSQQLRDFLGYEL
EELDGGAKSRLDATLDAGVHPDDLAGVKEQYARSLESGEPYRRKHRLRRFDGEYRWIETR
AAPMRDEKGAIVQWNVICLDVDREVRMQEELRLAQERLARAGQAASLAELSASIAHEVNQ
PLAAIVANSHACYRWLSADPVNIERAKITTERVIRDAKSAADVVSRIRALFKQSVENRGI
LVLSDVISEACSLVAAEALRRRIRLNIDVETNLAPVTVDRIQVQQVLVNLIRNGMEAMDA
VDDNKTVDVRMHQVDDEVRIEIGDNGNGVAFPERIFEPFFTTKENGMGMGLAISRSIVEA
HGGRLWAEKNEPRGARFVFTLPNVAKGAT