Protein Info for SM_b20846 in Sinorhizobium meliloti 1021
Annotation: xanthine dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 100% identity to sme:SM_b20846)Predicted SEED Role
"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)
MetaCyc Pathways
- purine nucleotides degradation II (aerobic) (11/11 steps found)
- adenosine nucleotides degradation II (5/5 steps found)
- purine nucleotides degradation I (plants) (10/12 steps found)
- adenosine nucleotides degradation I (7/8 steps found)
- guanosine nucleotides degradation II (4/4 steps found)
- guanosine nucleotides degradation III (4/4 steps found)
- inosine 5'-phosphate degradation (4/4 steps found)
- superpathway of purines degradation in plants (14/18 steps found)
- ureide biosynthesis (6/7 steps found)
- superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
- guanosine nucleotides degradation I (3/4 steps found)
- purine nucleobases degradation II (anaerobic) (16/24 steps found)
- caffeine degradation III (bacteria, via demethylation) (2/7 steps found)
- caffeine degradation IV (bacteria, via demethylation and oxidation) (2/10 steps found)
- theophylline degradation (1/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.1.4
Use Curated BLAST to search for 1.17.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92UJ2 at UniProt or InterPro
Protein Sequence (778 amino acids)
>SM_b20846 xanthine dehydrogenase (Sinorhizobium meliloti 1021) MDKSTLESHATITGPMHAPLRHDSAHKHVAGTADYIDDMPEPAGTLHGALGLTDRAHAEI LEMDLAAVAAVPGVVCVLTARDMPHSNDISPTHLHDEPVLADGRVEFHGQPAFAVIAETR DVARRAARLARMTYRDFLPAIDIIDAVATGGELVTPPLTLERGDAEGELERAPRRIQGHM RIGGQEHFYLEGHIALAIPGEDDEMTVWVSTQHPSEVQRMVAQVLGVPSNAVTVNVRRMG GGFGGKETQGNQFAALAAVAARKLRRAVKFRPDRDDDMTATGKRHDFLVNYDVGFDEEGR IRAVQANYAARCGFSADLSGPVTDRALFHADNAYFYPHVKLTSQPLKTNTVSNTAFRGFG GPQGMLGGERIIEEIAYALGKDPLEIRKLNFYGDAHSGRNVTPYHQKIEDNIISRIVDEL EASADYQARRAAIIEFNRSSRVIRKGIALTPVKFGISFTLTHLNQAGALVHIYTDGSVHL NHGGTEMGQGVYTKVAQVLADSFQIDIDRVKITATTTGKVPNTSATAASSGSDLNGMAAF DAARQIKERLVAFAAERWQTTAENVTFVANHVRIGDELVPFAQFVQEAYGARVQLSAAGF YATPGIHWDRAAGRGTPFYYFAYGAAVSEVSIDTLTGEYLVDRVDVLHDVGRSLNAAIDL GQIEGGFVQGMGWLTTEELWWDEKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENAEE TIGRSKAVGEPPLMLPISVVEALSMAVASVAGYRECPRLDTPATPERVLMAVERLRAG