Protein Info for SM_b20662 in Sinorhizobium meliloti 1021

Annotation: oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 258 transmembrane" amino acids 230 to 249 (20 residues), see Phobius details PF00106: adh_short" amino acids 12 to 205 (194 residues), 160.2 bits, see alignment E=8.7e-51 PF01370: Epimerase" amino acids 13 to 178 (166 residues), 24.2 bits, see alignment E=4.2e-09 PF08659: KR" amino acids 14 to 174 (161 residues), 46 bits, see alignment E=1.2e-15 PF13561: adh_short_C2" amino acids 20 to 235 (216 residues), 133.4 bits, see alignment E=2e-42

Best Hits

Swiss-Prot: 34% identical to 3BHDP_RUMGV: 3-beta-hydroxycholanate 3-dehydrogenase (NADP(+)) (RUMGNA_00694) from Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_4366)

MetaCyc: 34% identical to 3beta-hydroxysteroid dehydrogenase ([Ruminococcus] gnavus ATCC 29149)
RXN-17387 [EC: 1.1.1.393]; 1.1.1.393 [EC: 1.1.1.393]; 1.1.1.393 [EC: 1.1.1.393]; 1.1.1.393 [EC: 1.1.1.393]

Predicted SEED Role

"L-fuco-beta-pyranose dehydrogenase (EC 1.1.1.122)" (EC 1.1.1.122)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.122

Use Curated BLAST to search for 1.1.1.122 or 1.1.1.393

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92TX5 at UniProt or InterPro

Protein Sequence (258 amino acids)

>SM_b20662 oxidoreductase (Sinorhizobium meliloti 1021)
MAQGKGSGEGRIALVTGGGTGVGRGIAQALSAEGYSVVITGRRPDVLDAAAGEIGGRTGN
IVRAVVCDVGDPDQVAALFAAVRAEFARLDLLVNNAGSNVPPVPLEEVTFEQWNGIVAAN
LTGAFLCTQHAFRMMKAQTPRGGRIINNGSISAQTPRPNSAPYTATKHAITGLTKSTALD
GRMHDIACGQIDIGNAATDMTARMSTGVLQANGEVAAEPTIPIEHIAEAVVYMASLPLSA
NVLTMTVMATRMPLVGRG