Protein Info for SM_b20515 in Sinorhizobium meliloti 1021

Annotation: chemotaxis methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1161 PF01339: CheB_methylest" amino acids 10 to 183 (174 residues), 181.3 bits, see alignment E=7.6e-57 PF03705: CheR_N" amino acids 209 to 257 (49 residues), 54.9 bits, see alignment (E = 3.1e-18) PF01739: CheR" amino acids 271 to 453 (183 residues), 165.1 bits, see alignment E=7.6e-52 PF13596: PAS_10" amino acids 723 to 827 (105 residues), 94 bits, see alignment E=4.5e-30 PF08448: PAS_4" amino acids 732 to 831 (100 residues), 26.9 bits, see alignment E=2.6e-09 amino acids 852 to 959 (108 residues), 34 bits, see alignment E=1.7e-11 PF00989: PAS" amino acids 849 to 935 (87 residues), 29.7 bits, see alignment 3e-10 TIGR00229: PAS domain S-box protein" amino acids 850 to 962 (113 residues), 56.9 bits, see alignment E=1.1e-19 PF13426: PAS_9" amino acids 857 to 956 (100 residues), 46.8 bits, see alignment E=1.7e-15 PF07568: HisKA_2" amino acids 970 to 1021 (52 residues), 30.4 bits, see alignment (E = 1.9e-10) PF07536: HWE_HK" amino acids 970 to 1051 (82 residues), 104.9 bits, see alignment 1.7e-33

Best Hits

KEGG orthology group: K13924, two-component system, chemotaxis family, CheB/CheR fusion protein [EC: 2.1.1.80 3.1.1.61] (inferred from 95% identity to sme:SM_b20515)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80, 3.1.1.61

Use Curated BLAST to search for 2.1.1.80 or 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92W49 at UniProt or InterPro

Protein Sequence (1161 amino acids)

>SM_b20515 chemotaxis methyltransferase (Sinorhizobium meliloti 1021)
MDRELDPPIVAIGASAGGVQALQTFFDLMPSDTGATFVVIVHLDPHARSELANILAARTR
MPVTQVEDQARLESNHVYVIAPNRRLKVADGTIAALPFEEPHALRAPIDLFFRSLAEEHG
SEFAVILTGAGADGAIGVKAVKEAGGIVLVQDPEEAEYASMPRNAIDTEVADFVLPIREL
PHRVAELLARRDQLPSHPFRADDDDMIGRILAHVRGRTGHDFSQYKRATILRRIGRRAQI
ARRETFADYYNYLRENPEEAQALFSDFLISVTTFFRDPSAFEALAERVIPQLFDGKEVAD
AIRVWIPGCATGEETYTMGMLLIEEAARRDLSPEIQVFGSDLDEQALRIAREGRYPSTIE
SDLSEERLRRFFQREGDHYRVRRELRDVVLFASHSLLRDPPFSHLDMISCRNLLIYLDRQ
LQQQVCNTFHYALNAGGFLFLGSSESADHPGLFLTVDREARIYRAVAGGGARRPMVLPAL
LGPQKPEMKSTIIRTPAAGHVSDAAVHRQMLEKIAPPSMLVDESHHAIHLSENAGRFLRP
SGGPVSTDATDLVREEFRFDVRAALHRAFERDEPTLSMPILADLDGQPHRVYLQVKPVVQ
GTERTRHALVLFIEGEAIDKTQEVVLDTLDGRPTIDEAIRRLQEELQLAQNRLRLTSEES
ATATEELRAANEELQSMNEEYRSTAEELETSKEELQSINEELQTVNNELKLKLESISRAH
SDLQNLMAATDIATLFLDPSLRIKRFTPRLTEIFNVTPSDEGRPITDFTHYLKYKRLSDD
ARAVLETLRPLEHEVKSRNDGWYLVRMRPYRTVEDKIDGVVVTFLDISERRHAEEAAKES
GRRLEQEMRLVELSRSPIFVWDFDDGIMQWNRGSEELYGYSREEAIGRRKEELLKTAVPG
SSFDRLRRTLSEKGRWSGELNHTTKDGRVLTVESQIELVPFGERRLVLESTRDITDRKRW
ERRGQLLLNELSHRVKNTLAVVQSLARQTLRTTRSSEDFVERFEGRLAALASAHKLLVDS
EWRGAELDALARGQLDAYAGSDRRRLQIEGEPVTLPPDLATPFGLVLHELATNAAKYGAF
STGNGQIRLSWKLGNNGRRLGVIWQERGGPPVEPPSEQGFGGVLIEKSLPGSTVHRDFQP
DGVVCTIDIELPEIRPDGAEN