Protein Info for SM_b20456 in Sinorhizobium meliloti 1021

Annotation: dehydrogenasereductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 248 PF00106: adh_short" amino acids 9 to 197 (189 residues), 189.4 bits, see alignment E=7.8e-60 PF08659: KR" amino acids 11 to 183 (173 residues), 47.9 bits, see alignment E=2.3e-16 PF13561: adh_short_C2" amino acids 18 to 247 (230 residues), 203.4 bits, see alignment E=6.2e-64

Best Hits

Swiss-Prot: 39% identical to 3BHD1_EGGLE: 3-beta-hydroxycholanate 3-dehydrogenase (NAD(+)) 1 (Elen_0198) from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255)

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20456)

MetaCyc: 39% identical to NAD-dependent bile acid 3beta-dehydrogenase (Eggerthella lenta DSM 2243)
RXN-11472 [EC: 1.1.1.391]; 1.1.1.391 [EC: 1.1.1.391]; 1.1.1.391 [EC: 1.1.1.391]; 1.1.1.391 [EC: 1.1.1.391]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] reductase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.391

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WA6 at UniProt or InterPro

Protein Sequence (248 amino acids)

>SM_b20456 dehydrogenasereductase (Sinorhizobium meliloti 1021)
MTSISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRA
VAIRADNRDAEAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFDEVMAVNFRA
PFVAIRSASRHLGDGGRIITIGSNLAELVPWPGISLYSASKAALAGLTKGLARDLGPRGI
TVNIVHPGSTDTDMNPADGDHAEAQRERIATGSYGEPQDIAGLVAWLAGPQGKFVTGASL
TIDGGANA