Protein Info for SM_b20450 in Sinorhizobium meliloti 1021

Annotation: regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 431 to 453 (23 residues), see Phobius details PF00672: HAMP" amino acids 453 to 502 (50 residues), 44.5 bits, see alignment 1.5e-15 PF07228: SpoIIE" amino acids 591 to 785 (195 residues), 134.2 bits, see alignment E=5.8e-43

Best Hits

KEGG orthology group: K07315, sigma-B regulation protein RsbU (phosphoserine phosphatase) (inferred from 100% identity to sme:SM_b20450)

Predicted SEED Role

"Serine phosphatase RsbU, regulator of sigma subunit" in subsystem SigmaB stress responce regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WB1 at UniProt or InterPro

Protein Sequence (786 amino acids)

>SM_b20450 regulatory protein (Sinorhizobium meliloti 1021)
MSLPGENTTRLGLRSFRAKFVLVVGSAVLFDLLVTGGLALWNVQRLSRDAAAEVGRGLEE
ANQDYIRSYAATTAARVNLLLNQVHSDVGTLAGVLQEQIDRPVRKSQIGEAMARGAPGTV
TVAYDQKGGWAQNLPGPPSVVSVWGYLLDQNHLPLPDVQTDIENSAVLDLVAPSLLANGQ
SKLQMYYIGPKERPIFRTAPYTDQAQTFDKLYPGHNSAEFWSFFFPGLYESWEQWARDPK
SRPVNGDITQTAPYTDAITGKLIVSFFQPLWSRDRSRVLGAAGTDITLDQLAEIVENVKV
AETGFGFLTMSDGNVVAINPVGEKVIGLRASNAAASGGVTGLDRSLRRSVQPEIAQLPLG
EDGLLKHIFLEENGERVPYLVVLKQLQPTNLWASGPVRREAMLLGIAVPEREIYASLFAA
QAGISEATNRILIYQVLALLVSLFFVIAAVFAISKRITGGISALANAAKRIEAKDYSVRV
DIPTRDEVGDAGAAFNRMAEEISFHTENLEQLVEDRTKEIEEANLQISALNQQLRSENLR
LGAELAVARRIQMMVLPKAGELEEIAELEIAAYMRPADEVGGDYYDVLQDGKRLKIGIGD
VTGHGLESGVLMLMVQSVARALQEMGEMEPAQFLNRVNRAIYKNLVRTRTNKHLSLAFLD
YDGARLTLSGQHEELIVIRDLERVERIDTLDLGLPIGLEPDISAFVATREISFGRGDMII
LHTDGVTEAESGTGELFGIERLCESARCRYGSSAEDVKSGIIEDLMAHIGTQKIHDDITL
VVMRHR