Protein Info for SM_b20404 in Sinorhizobium meliloti 1021

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 746 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF20256: MoCoBD_2" amino acids 58 to 178 (121 residues), 98.9 bits, see alignment E=5.8e-32 amino acids 572 to 687 (116 residues), 66.3 bits, see alignment E=5.2e-22 PF01315: Ald_Xan_dh_C" amino acids 214 to 262 (49 residues), 33.1 bits, see alignment 9e-12 PF02738: MoCoBD_1" amino acids 312 to 467 (156 residues), 74.5 bits, see alignment E=1.1e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20404)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WF0 at UniProt or InterPro

Protein Sequence (746 amino acids)

>SM_b20404 aldehyde dehydrogenase (Sinorhizobium meliloti 1021)
MGILQEEITRRSVIASAGGLVVGFSLGRAFAQELPPATPPAPPVSLPGSLDDERFLDSWI
RIDPDSSVTVFTGKAELGQGIRTALLQVAAEELEVDPAEIRLITADTGRTPNEGFTAGSQ
SMQNSGAAIRNAAAQVRALLLAEAARRFGLAATELRAENKAVLAKDGRRATYGELVSGRM
LHVEAQPQSALKPPGTFRVIGKTLPRVDIPGKVTGQPAYVHDLRLEAMLHARVVRPPSPA
ARLTEVDASAAEALPGVASVVRDGNFLAVVASKEFQAVNAMRALAAAARWQESETLPDQT
DLPAELQRLESEAGTVAETGMLSSDGKIFEATFSRPYQIHGSIGPSCAVAQMKADGTLDV
WSHTQGVFPDRAAIAEMLAMPEDKVHVIHMEGSGCYGHNGADDAAADAALIASKLPGKPI
RVQWMREQEHSWEPYGPAMLMKISAALDDQGRIASWAYDLWSNTHSTRPGGAGALLAARH
KAEAIQPKPAKLNISPSGNGDRNADPLYVIPNKRVLWHFLADMPLRVSALRALGAYANVF
AIESTIDELALMADADPVEFRLRHMEDPRARAVIELAAQRFGWDKAQMPRNRGRGFGFAR
YKNLAAYLAVAMEVDVEPETGSVHVIRAVSAIDSGEIVNPDGIRNQTEGGILQSISWTLY
EAVAFDRTRITSTDWSSYPILRFASVPESVEIHIVERPGEPFLGTGEAAQGPAAAAVANA
IRDATGKRLYDLPFTRDRIRSAVGRA