Protein Info for SM_b20371 in Sinorhizobium meliloti 1021

Annotation: ribose-5-phosphate isomerase B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01120: ribose 5-phosphate isomerase B
  • amino acids 2 to 143 (142 residues), 149.3 bits, E=7.1e-48
• PF02502: LacAB_rpiB
  • amino acids 3 to 141 (139 residues), 169.6 bits, E=1.9e-54
• TIGR00689: sugar-phosphate isomerase, RpiB/LacA/LacB family
  • amino acids 3 to 146 (144 residues), 152 bits, E=1.1e-48

Best Hits

Swiss-Prot: 44% identical to RPIB_ECOLI: Ribose-5-phosphate isomerase B (rpiB) from Escherichia coli (strain K12)

KEGG orthology group: K01808, ribose 5-phosphate isomerase B [EC: 5.3.1.6] (inferred from 100% identity to smk:Sinme_3807)

MetaCyc: 44% identical to allose-6-phosphate isomerase / ribose-5-phosphate isomerase B (Escherichia coli K-12 substr. MG1655)
Ribose-5-phosphate isomerase. [EC: 5.3.1.6]; 5.3.1.- [EC: 5.3.1.6]

Predicted SEED Role

"Ribose 5-phosphate isomerase B (EC 5.3.1.6)" in subsystem Calvin-Benson cycle or D-ribose utilization or LMPTP YwlE cluster or Pentose phosphate pathway (EC 5.3.1.6)

MetaCyc Pathways

• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (22/26 steps found)
• Bifidobacterium shunt (14/15 steps found)
• Rubisco shunt (10/10 steps found)
• superpathway of glucose and xylose degradation (15/17 steps found)
• Calvin-Benson-Bassham cycle (12/13 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (11/12 steps found)
• pentose phosphate pathway (8/8 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (21/27 steps found)
• pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
• ethene biosynthesis V (engineered) (19/25 steps found)
• oxygenic photosynthesis (13/17 steps found)
• pentose phosphate pathway (non-oxidative branch) II (5/6 steps found)
• formaldehyde assimilation II (assimilatory RuMP Cycle) (7/9 steps found)
• D-allose degradation (2/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Carbon fixation in photosynthetic organisms
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.6

Use Curated BLAST to search for 5.3.1.6

Sequence Analysis Tools

See Q92WI2 at UniProt or InterPro

Protein Sequence (148 amino acids)

>SM_b20371 ribose-5-phosphate isomerase B (Sinorhizobium meliloti 1021)
MRIVIGSDHAGFHLKATIIDHVTSLGHEVYDAGSYDANPVDFPDIAKMVTSSIIEGKADR
GLMVCGTGVGASIAANKVKGIRAAVCHDVHSAHQSVEHDDVNVMCIGAQIVGAWLARDLV
AAYLAAEFSTDEDFRRRVRKLAEMDEQR