Protein Info for SM_b20346 in Sinorhizobium meliloti 1021

Annotation: efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 384 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 42 to 362 (321 residues), 234.9 bits, see alignment E=5.9e-74 PF16576: HlyD_D23" amino acids 65 to 275 (211 residues), 70 bits, see alignment E=2.7e-23 PF13533: Biotin_lipoyl_2" amino acids 72 to 114 (43 residues), 36.8 bits, see alignment 3.9e-13 PF13437: HlyD_3" amino acids 178 to 272 (95 residues), 50.6 bits, see alignment E=4.3e-17

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20346)

Predicted SEED Role

"RND efflux membrane fusion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WK7 at UniProt or InterPro

Protein Sequence (384 amino acids)

>SM_b20346 efflux protein (Sinorhizobium meliloti 1021)
MFSGSALNRPFVARLLTAILLGAVLSGCSQEKVETKETIRPVKVVEIAAAGEPRELHYSG
SVRARTEMNLGFRVGGKITERLVNIGDRVKPGDILARIDATDYRLAVTSAEANLLAAEKQ
VQTTALAKLRAEQLFTKSFSSQAQLDQATLLYDQAVSTRDAAASSLSQAKNQVSYTDLKA
DQNGIVTAVNADIGQVVGTGTPVVTVAVDGEKEVEIAVPEIDVTEFKPGKPVGVRFWSND
MLVLDGHVREVSGSADQRSRTFSVRVSLPNDERVLLGMTATVEAAAASSAPLVSIPLSAL
SKKDGQNIVWIVDRDFSTVHARPIKLADFADNGVRVVDGLGAGDLVVAAGTQFMAEDLKV
RLQAGEQQSAEQQSARAETPEILR