Protein Info for SM_b20333 in Sinorhizobium meliloti 1021

Annotation: transporter protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 706 transmembrane" amino acids 53 to 75 (23 residues), see Phobius details amino acids 95 to 113 (19 residues), see Phobius details amino acids 133 to 154 (22 residues), see Phobius details amino acids 186 to 206 (21 residues), see Phobius details amino acids 232 to 256 (25 residues), see Phobius details amino acids 271 to 293 (23 residues), see Phobius details amino acids 305 to 325 (21 residues), see Phobius details amino acids 360 to 378 (19 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 443 to 463 (21 residues), see Phobius details amino acids 489 to 510 (22 residues), see Phobius details amino acids 516 to 536 (21 residues), see Phobius details PF02028: BCCT" amino acids 57 to 539 (483 residues), 654.2 bits, see alignment E=5.5e-201 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 95 to 540 (446 residues), 538.9 bits, see alignment E=4.8e-166

Best Hits

Swiss-Prot: 100% identical to BETS_RHIML: Glycine betaine/proline betaine transporter BetS (betS) from Rhizobium meliloti

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20333)

Predicted SEED Role

"High-affinity choline uptake protein BetT" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WM0 at UniProt or InterPro

Protein Sequence (706 amino acids)

>SM_b20333 transporter protein (Sinorhizobium meliloti 1021)
MQNRVVSCRFTGSTARRATMPEGIRGRSHILFLVPLSRAESVGRLHQVQRFKVNLPVFVG
SVAVIALFVGIGVIAPKRAESIFSGMQTAILSGFGWLYLLSVAVFLFSMLFLAFSRYGEL
KLGPDDSEPEFRYLSWIAMLFAAGMGIGLMYFAVGEPMTHFASPPEAEPLTIAAQREAMS
VTFFHWGVHAWAIYSVVGLSLAYFGYRYNLPLTVRSGLYPLLKEGIHGPIGHVVDIFAIC
GTMFGLATSLGFGILQINSGLNYLLGIPQSIYVQLLLVTVVTAIATISVVTGVEKGVRIL
SETNLFLAVLLMLFVLVVGPTGTLMRDFVQNIGLYLDSLVLRTFNIYAYEPRPWIDSWTL
FYWAWWISWSPFVGMFIARISRGRTVREFVTAVLFVPAMFTFLWMTVFGNTAIYVDTTIA
NGELARDVKADLSVALFQFFEYLPWPAVTSTLAVLLVSIFFVTSSDSGSLVIDTIASGGE
TATPALQRIFWCSLSGIVAAVLLSTGGLTALQSATISTALPFSLVMLILVWSLFVGMRAD
LARTQSPGSLGPRAYPASGVPWQRRLAMTLSTPDRRAVEKFLQASVLPALEAVARELTRR
SRPASVGRDAETGALTLTVPAEGHRDFVYGVQMSEHKLPAFTAYDATVADVRYEARTFFS
DGSRGYDIMGMADNQIINDVLFQFERYTGFVRSPESSLLATSPEER