Protein Info for SM_b20324 in Sinorhizobium meliloti 1021

Annotation: ThuR, regulatory protein for trehalosemaltose transport system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 338 PF00356: LacI" amino acids 2 to 47 (46 residues), 39.3 bits, see alignment 6.8e-14 PF00532: Peripla_BP_1" amino acids 61 to 310 (250 residues), 87.2 bits, see alignment E=2.1e-28 PF13377: Peripla_BP_3" amino acids 169 to 332 (164 residues), 97.3 bits, see alignment E=1.7e-31

Best Hits

Swiss-Prot: 48% identical to AGLR_RHIME: HTH-type transcriptional regulator AglR (aglR) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 100% identity to smk:Sinme_3855)

Predicted SEED Role

"Maltose operon transcriptional repressor MalR, LacI family" in subsystem Maltose and Maltodextrin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7ANS3 at UniProt or InterPro

Protein Sequence (338 amino acids)

>SM_b20324 ThuR, regulatory protein for trehalosemaltose transport system (Sinorhizobium meliloti 1021)
MKLKEFAKQLGLSPTTVSRALSGYPEVSEKTRKRVAEEAVRLGYRPNINAVRLVTGRAGA
IGVVMGRNEFQFSEFMSGMAERLDSEDIDILVSPVADHDMKAELQLYSRLATSGRVDAVI
IHSPKPNDERILLLHKLGIPFLVHGRSETNVPHAWLDIDNEGAIRRATSHLLDLGHRRIA
LINGRDGLTFTLHRDKGYREALEQRGLPFDPRLVTHGQFTDEIGFRSARSFLEQSPRPTA
FVAGSMMTALGVYRAVRSVGLVVGKDISVIAHDDVFPYLTADNMVPSLSTSRSSLRAAGA
RSADLTLQLLTGRPATEIHELWPVELILRESTGPAPEA