Protein Info for SM_b20249 in Sinorhizobium meliloti 1021

Annotation: myo-inositol-1-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 63% identical to INO1_MYCS2: Inositol-3-phosphate synthase (ino1) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

KEGG orthology group: K01858, myo-inositol-1-phosphate synthase [EC: 5.5.1.4] (inferred from 100% identity to smk:Sinme_3924)

MetaCyc: 63% identical to inositol-1-phosphate synthase subunit (Mycobacterium tuberculosis H37Rv)
Inositol-3-phosphate synthase. [EC: 5.5.1.4]

Predicted SEED Role

"Inositol-1-phosphate synthase (EC 5.5.1.4)" in subsystem Di-Inositol-Phosphate biosynthesis (EC 5.5.1.4)

MetaCyc Pathways

myo-inositol biosynthesis (2/2 steps found)
phosphatidylinositol biosynthesis I (bacteria) (1/3 steps found)
di-myo-inositol phosphate biosynthesis (1/4 steps found)
mycothiol biosynthesis (1/6 steps found)
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza) (1/7 steps found)
1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium) (1/7 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.5.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92WU0 at UniProt or InterPro

Protein Sequence (367 amino acids)

>SM_b20249 myo-inositol-1-phosphate synthase (Sinorhizobium meliloti 1021)
MRSNSIRVGLVGVGNCASSLVQGLTFYRDAKEDEPVPGLMHTNLGGYHVGDIEVSAAFDV
AASKVGRDVAEAIYAAPNNTFRFADVPATGVVVERGRTLDGIGRYLREEIEESDAPAADV
AEVLRQTGTDVLVSYLPVGSEVATRWYAEQALAAGCGFVNCIPVFIASDKSWQRKFAERG
LPLIGDDIKSQVGATIVHRLLANLFRDRGVRIDRTYQLNFGGNTDFLNMLERERLESKKI
SKTQSVVSQMDIPLAAGDIHVGPSDHVPWLADRKFAYIRVEGTTFGNVPLNVELKLEVWD
SPNSAGVVIDAVRCAKLAIDRGIAGPLIAPSSYFMKSPPQQFTDAEARRRLEEFIAGDTD
ALLGAAE