Protein Info for SM_b20205 in Sinorhizobium meliloti 1021

Annotation: pyrroloquinoline quinone biosynthesis protein PqqB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 303 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR02108: coenzyme PQQ biosynthesis protein B" amino acids 8 to 303 (296 residues), 372 bits, see alignment E=1e-115 PF12706: Lactamase_B_2" amino acids 57 to 271 (215 residues), 136.7 bits, see alignment E=4e-44

Best Hits

Swiss-Prot: 100% identical to PQQB_RHIME: Coenzyme PQQ synthesis protein B (pqqB) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K06136, pyrroloquinoline quinone biosynthesis protein B (inferred from 99% identity to smk:Sinme_3967)

Predicted SEED Role

"Coenzyme PQQ synthesis protein B" in subsystem Coenzyme PQQ synthesis or Pyrroloquinoline Quinone biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q9EXV1 at UniProt or InterPro

Protein Sequence (303 amino acids)

>SM_b20205 pyrroloquinoline quinone biosynthesis protein PqqB (Sinorhizobium meliloti 1021)
MNKTSDLRIIVLGAAAGGGLPQWNCGCRNCAMARDPASGLRPQTQSSLAVSLDGESWTVF
NASPDIRQQVQDNCPLQPRRLRHSPIESVVLTNGDIDHLAGLLVLREKQAFTLFSTGAVG
RIVSDNPVFQVLDPELVSRKTIEIDEAFSPLSGLDARLFAVPGKVPLFLEDGEPDLGIEG
EHTVGLELEATGRRVYYVPGCAMMTDSLAARLRDADAVFFDGTLFSDDEMILTGTGRKTG
RRMGHMPIDGEGGSLDALDLLNIRRKIYVHINNTNPIWRAGSERERVEARGFEIGYDGME
VRL