Protein Info for SM_b20128 in Sinorhizobium meliloti 1021

Annotation: deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07969: Amidohydro_3
  • amino acids 65 to 118 (54 residues), 35.2 bits, 1.1e-12
  • amino acids 117 to 400 (284 residues), 89.5 bits, E=3.6e-29
• PF01979: Amidohydro_1
  • amino acids 72 to 417 (346 residues), 62.8 bits, E=3.4e-21

Best Hits

KEGG orthology group: K01485, cytosine deaminase [EC: 3.5.4.1] (inferred from 100% identity to sme:SM_b20128)

Predicted SEED Role

"Cytosine deaminase (EC 3.5.4.1)" (EC 3.5.4.1)

MetaCyc Pathways

• pyrimidine nucleobases salvage II (2/2 steps found)
• pyrimidine ribonucleosides salvage III (2/2 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.1

Use Curated BLAST to search for 3.5.4.1

Sequence Analysis Tools

See Q92X34 at UniProt or InterPro

Protein Sequence (437 amino acids)

>SM_b20128 deaminase (Sinorhizobium meliloti 1021)
MEWSHSMHTVLGTRHGGARRALLLRGCRIAGEAAAADERDILVGEDGRIASIGHRLEVGP
DVIGVDLRGALVSPGFVDVHQHLDKTGVLKFTPNPSGTLQGAREAFARYARQAPEDDVTR
RAARTMERCLARGTTAIRSHINVDKDAGFNGINALARLRSEWADRLTLQLVAFMTPHPNQ
DIEWLEKNIDAAVEQADAVGGTPAVAEDPMRYLDILFAAAERHGRPIDLHLDEHLSPERP
LFDAVFERVRRFGLQGRTVLGHASVLSALPRKEFERIRDQMIDLDIAVVTLPAANLYLQG
RSHDMLPPRGLTRVAELIRAGVAIATASDNIQDPFVPTGSGDMLEIARWTLLAGHLRGDE
LATAYDMITAIPARMMNLTDYGIREGTWADLVVTDCEDVSALVGGGPDCIQVLAKGRPVA
APASPAVEAIRALEDVP