Protein Info for SGL_RS16085 in Synechocystis sp000284455 PCC 6803

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 transmembrane" amino acids 34 to 36 (3 residues), see Phobius details amino acids 41 to 58 (18 residues), see Phobius details amino acids 78 to 95 (18 residues), see Phobius details amino acids 101 to 121 (21 residues), see Phobius details amino acids 256 to 277 (22 residues), see Phobius details amino acids 284 to 308 (25 residues), see Phobius details amino acids 597 to 614 (18 residues), see Phobius details amino acids 620 to 640 (21 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 78 to 639 (562 residues), 601.6 bits, see alignment E=2.8e-184 TIGR01494: HAD ATPase, P-type, family IC" amino acids 108 to 612 (505 residues), 297.8 bits, see alignment E=1.7e-92 PF00122: E1-E2_ATPase" amino acids 136 to 316 (181 residues), 162 bits, see alignment E=1.1e-51 PF00702: Hydrolase" amino acids 332 to 549 (218 residues), 139.7 bits, see alignment E=1.6e-44

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to syn:slr0797)

Predicted SEED Role

"Cadmium-transporting ATPase (EC 3.6.3.3)" in subsystem Cobalt-zinc-cadmium resistance (EC 3.6.3.3)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (642 amino acids)

>SGL_RS16085 heavy metal translocating P-type ATPase (Synechocystis sp000284455 PCC 6803)
MVVTPPSSAFRFSNLFKDHPDAVAAIACGGLVFLGWQMLNLGWLGIAFFVLTAAYVIGGF
DNAREGLTTLFEEKEFDVDLLMIVAALGAAGLGLWRREYTLIVDGAVLILIFAISGALEG
YAMQRTERSIQGLMSLTADVARVLRNGQEQTIPISELKMGDQVLVKPGELVPTDGLVIEG
FSTLNQASITGESMPVEKAIGDEVFAGTINGNGVLRLKIHQPPESSLIQRVIRLVQQAQT
EAPPSQQFIERFECGYAKVIVIAGLLLGTLPPFLLGWSWEETIYRALIFLVVASPCALMA
SIMPALLSGIANGARQGILFKNGAQLERIGRVRVIAFDKTGTLTTGKPEVVNILATQPST
DKLLQIAAALESLSEHPIGEAIADFTRQQNQAWATARNVQAQAGQGIIGDIEGQQAIVGK
AVFVQAQVNHVATNLIEQSQQWEAEGKTVVWVAYAGEILGLIAVADTVRPTAAQAIARLK
RLGIERIVMLTGDNSRTAHSIAQQVGVNQVYAELLPEDKVDVIRQLQKQYQSVAMVGDGI
NDAPALAQASVGIAMGAAGSDVALETADIVLMADRLERLEHAIRLGRRAQGVVKQNIVFA
LGFVMILLIANFAGNITLPFGVLGHEGSTVIVTLSGLRLLRG