Protein Info for SGL_RS11860 in Synechocystis sp000284455 PCC 6803

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1578 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details amino acids 202 to 221 (20 residues), see Phobius details amino acids 240 to 258 (19 residues), see Phobius details amino acids 509 to 528 (20 residues), see Phobius details amino acids 540 to 563 (24 residues), see Phobius details amino acids 861 to 882 (22 residues), see Phobius details PF03924: CHASE" amino acids 305 to 465 (161 residues), 123.3 bits, see alignment E=5.4e-39 TIGR00229: PAS domain S-box protein" amino acids 709 to 834 (126 residues), 71.2 bits, see alignment E=8.6e-24 amino acids 1018 to 1145 (128 residues), 45.8 bits, see alignment E=6.3e-16 PF00989: PAS" amino acids 713 to 825 (113 residues), 41 bits, see alignment 8.6e-14 PF13188: PAS_8" amino acids 714 to 769 (56 residues), 28.4 bits, see alignment (E = 5.8e-10) PF13426: PAS_9" amino acids 723 to 827 (105 residues), 55.8 bits, see alignment 2.4e-18 PF13185: GAF_2" amino acids 856 to 1001 (146 residues), 85 bits, see alignment E=2.9e-27 PF01590: GAF" amino acids 910 to 1000 (91 residues), 51.9 bits, see alignment 5.7e-17 PF08447: PAS_3" amino acids 1045 to 1132 (88 residues), 72.9 bits, see alignment 1.1e-23 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 1146 to 1315 (170 residues), 144.2 bits, see alignment E=3.1e-46 PF00990: GGDEF" amino acids 1150 to 1311 (162 residues), 165 bits, see alignment E=6.2e-52 PF00563: EAL" amino acids 1332 to 1565 (234 residues), 246.1 bits, see alignment E=1.6e-76

Best Hits

KEGG orthology group: None (inferred from 100% identity to syn:sll0267)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1578 amino acids)

>SGL_RS11860 EAL domain-containing protein (Synechocystis sp000284455 PCC 6803)
MSIMPPPPSSVPPHQGHGFWRGAVLLVLIFLIIFGGVAVAHWRIEMVSQQMRQQLLSQVE
MVSLNLNFRLFQELSFTPQDLENPSFQRLHNQMAAYAQTFEHRSIYTMVIRSGKILFGPD
SLKSGDFLARDPGAVYKNPPEAVRQLFELPSKKLVIGPYHSERGNFVSAYAPILQPQSER
VLVIVAMDMEARQWHQKLQQKLWTPLLFSVGLIALILGGDYLLQERRRWRNSFITNQGEA
LATAIVGLFLTLALTAVVQENSLLNSQRNFSQLAIPRANLFAQKLWELQNYGLSSLNSFM
ESSAEVTRAEFARFTLPMIRKLSIQAWEWIPKVTAADRENFERRARQDGIENFQIFELNR
RGKPVPAEGREVYYPIFYAEPLAGNDIALGFDVSSNESAKMALDEALENRLPTATNPLTL
IQELGKQRGIVAYSPVFADGNLENPPMGVAAVVLRLNDFLTQTFGEISFGDKSLELQWLQ
LSVDRSPLVLASSAPSPFSMNNWQSNKELFQVYPLFIFGRAYALLLWPGPEFNQNYPKQM
AMVAFGVGTGITVLVTIIVAIITNSQANLTHQIRQRTKELRATLGQLRERVKEMDCLVAI
AQMGQQADLVLEEFLQNTVDLLPLAFRYEKLASARLTWGNSIYQSPNYQKTDYCLIAEFQ
TEHFHRGQLEVCYGEERDFLPEEKALLNTVSQFLSRFLESHYTEIILERNERNYREIFNS
THEAIFIQDAHQATVLDVNQPMLTMYGYGNKEEVIGRPIGDFSADKPGKTEAEIEQKLRQ
ARNAEPQMFEWLAKKQDGSLFWAEVSIQPTVIDGKSRLLAVVRDISERKQNQQRIEYLSR
LYATLSQVNRAIIENRERDDLFRAICDVGVAVGQFSLIWFGLIDPDRQTIIPYMAGGHTT
AYLENIRITFKDEPAGRGPTGTAAREGRLVICSNISQDPKMAPWRGSAMRYGFLSSAAVP
IRQGGQVVAVLTFYSQEAGFFSEDEQDLLQEISDNLSFALDAIQLDQANQRAQNQLGENE
ERLRLALEAANQGFYDLNLQTGQAVVSPQYGQILGYDPQYFQETEQRWLERIHPQDQQRV
REIYDQYIQGKIPRYAVECRQRTMAGQWKWLLSLGKIVEWDSQGKPLRMLGILTDVTERK
QAEAQIENLAYYDPLTALPNRRLLLDRAENALALAQRSKHFGAIVLIDLDGFKTLNDARG
HDSGDRLLQMVAKRLADSLRDSDTVARLGGDEFIVLLPELAHDRELAARLGLGVGEKIRQ
ALATPFTLEAEQVQISGSIGITLFPKLNEKVSDLFKEADTAMYQAKKAGRDKVCLFESQM
QLEVESRFALEADLRSALEQKQFQVYLQPQVDSHGVWIGAEALLRWNHPGRGFIPPNIFI
PIAEEIGLIGGIGDFVLEQVCQYLARLQQLGLTLRIAINVSPRQFRQANFAKEIKNLLAC
TGVDPYRLTLEVTEGLIVEDTHQAIATMFELQTLGIHFSVDDFGTGYSSLSYLKRLPLNE
LKIDRAFVQDAPQDLNNAALVEAIISVARTFNLAIVAEGVETEEQVQFLAQLGCNFYQGY
FYGRPMPIDEFHQKLTAS