Protein Info for SGL_RS06520 in Synechocystis sp000284455 PCC 6803

Annotation: hydrogenase expression/formation protein HypE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 345 TIGR02124: hydrogenase expression/formation protein HypE" amino acids 14 to 345 (332 residues), 455.3 bits, see alignment E=5.5e-141 PF00586: AIRS" amino acids 46 to 157 (112 residues), 78.8 bits, see alignment E=4.2e-26 PF02769: AIRS_C" amino acids 170 to 317 (148 residues), 105.3 bits, see alignment E=3.8e-34

Best Hits

Swiss-Prot: 47% identical to HYPE_RHOCA: Carbamoyl dehydratase HypE (hypE) from Rhodobacter capsulatus

KEGG orthology group: K04655, hydrogenase expression/formation protein HypE (inferred from 100% identity to syn:sll1462)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypE" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (345 amino acids)

>SGL_RS06520 hydrogenase expression/formation protein HypE (Synechocystis sp000284455 PCC 6803)
MNLVCPVPLDRYPQVLLAHGGGGKLSQQLLKQIFLPAFGASETGSHDAAVFTANQSSLAF
TTDSYVINPLFFPGGDIGSLAVHGTVNDLAMAGATPRYISVGFILEEGLPMETLWRVAQS
LGQAAQNCGVEILTGDTKVVDRGKGDGIFINTSGIGSLDHQQTIHPNQVQVGDRLILSGD
LGRHGMAIMAVRQGLEFETTIESDSAPVHREVQALLSAGIPIHCLRDLTRGGLASAVNEI
AQTSGVTMALRETLIPVEAEVQAACELLGFDPLYVANEGRFLAIVPPEAEQKTVEILQTF
HPQATAIGTVTGKSAQTLGLVSLESSIGAPRLLDMISGEQLPRIC