Protein Info for SGL_RS03035 in Synechocystis sp000284455 PCC 6803

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 PF00072: Response_reg" amino acids 11 to 123 (113 residues), 104.9 bits, see alignment E=2.8e-34 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 284 to 450 (167 residues), 179.1 bits, see alignment E=3e-57 PF00990: GGDEF" amino acids 288 to 449 (162 residues), 196 bits, see alignment E=3.6e-62

Best Hits

KEGG orthology group: K02488, two-component system, cell cycle response regulator (inferred from 100% identity to syn:sll1673)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>SGL_RS03035 diguanylate cyclase (Synechocystis sp000284455 PCC 6803)
MENTDEKKGNILLVDDLPNNLQLLSDLLINLGYTVRSVTSGKMALRTLQVKRPDLILLDI
KMPDMDGYQVCEMIKKEEELQDIPIIFISALGDTFDKVKAFECGGVDYITKPFQIEEVVA
RIEGQFTIQRQRIALKREVRKRREAEEVLYQSRALLSSVLNSALDGIAAMQAVRNPQTGD
IEDFRCLVINPILSKAFNRSREDLIGRVLLKRFLQRLDPQLFDQFVNLVETGTFLTQDIY
FPIANSDWYHFVAVKLGDGFAVTVRDITDRKRMELELQAANQQLQLLANIDGLTHIANRR
RFDEYLAQEWQRHCREQKPLSLILVDIDYFKAYNDLYGHQKGDDCLQKVANTLVDIAKRI
TDLVARYGGEEFVIVLPNTNRQDALAMAENMLQAIAALAIPHEGSSVSKYVTISIGVSSI
IPMPEDTIERIISEADQALYSAKSQGRNRAIA