Protein Info for SGL_RS02985 in Synechocystis sp000284455 PCC 6803

Annotation: HhoA/HhoB/HtrA family serine endopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 394 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details PF13365: Trypsin_2" amino acids 112 to 251 (140 residues), 122.5 bits, see alignment E=7.5e-39 PF00089: Trypsin" amino acids 113 to 272 (160 residues), 81.3 bits, see alignment E=2.8e-26 PF13180: PDZ_2" amino acids 287 to 385 (99 residues), 48.9 bits, see alignment E=2e-16 PF00595: PDZ" amino acids 305 to 371 (67 residues), 34.9 bits, see alignment E=5e-12 PF17820: PDZ_6" amino acids 322 to 364 (43 residues), 48.2 bits, see alignment 2.2e-16

Best Hits

Swiss-Prot: 100% identical to HHOA_SYNY3: Putative serine protease HhoA (hhoA) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 100% identity to syn:sll1679)

Predicted SEED Role

"Protease Do (EC 3.4.21.-)" (EC 3.4.21.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (394 amino acids)

>SGL_RS02985 HhoA/HhoB/HtrA family serine endopeptidase (Synechocystis sp000284455 PCC 6803)
MKYPTWLRRIGGYLLAFAVGTAFGIANLPHAVAAADDLPPAPVITAQASVPLTSESFVAA
AVSRSGPAVVRIDTETVVTRRTDPILDDPFFQEFFGRSFPVPPRERRIAGQGSGFIIDNS
GIILTNAHVVDGASKVVVTLRDGRTFDGQVRGTDEVTDLAVVKIEPQGSALPVAPLGTSS
NLQVGDWAIAVGNPVGLDNTVTLGIISTLGRSAAQAGIPDKRVEFIQTDAAINPGNSGGP
LLNARGEVIGINTAIRADATGIGFAIPIDQAKAIQNTLAAGGTVPHPYIGVQMMNITVDQ
AQQNNRNPNSPFIIPEVDGILVMRVLPGTPAERAGIRRGDVIVAVDGTPISDGARLQRIV
EQAGLNKALKLDLLRGDRRLSLTVQTAQLRNPTS