Protein Info for Rv3823c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved integral membrane transport protein MmpL8

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1089 transmembrane" amino acids 43 to 63 (21 residues), see Phobius details amino acids 218 to 237 (20 residues), see Phobius details amino acids 241 to 268 (28 residues), see Phobius details amino acids 272 to 292 (21 residues), see Phobius details amino acids 319 to 341 (23 residues), see Phobius details amino acids 348 to 371 (24 residues), see Phobius details amino acids 403 to 423 (21 residues), see Phobius details amino acids 871 to 890 (20 residues), see Phobius details amino acids 897 to 922 (26 residues), see Phobius details amino acids 928 to 949 (22 residues), see Phobius details amino acids 968 to 1012 (45 residues), see Phobius details amino acids 1014 to 1035 (22 residues), see Phobius details PF03176: MMPL" amino acids 75 to 401 (327 residues), 356.5 bits, see alignment E=1.3e-110 amino acids 679 to 1047 (369 residues), 285.3 bits, see alignment E=5.6e-89 PF12349: Sterol-sensing" amino acids 240 to 375 (136 residues), 24.9 bits, see alignment E=1.7e-09

Best Hits

Swiss-Prot: 100% identical to MMPL8_MYCTU: Sulfolipid-1 exporter MmpL8 (mmpL8) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mtu:Rv3823c)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1089 amino acids)

>Rv3823c Conserved integral membrane transport protein MmpL8 (Mycobacterium tuberculosis H37Rv)
MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPT
VPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSY
KELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARV
ADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITM
VLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLR
QGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAA
VTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLA
RYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQR
VSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANL
MASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTID
ADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQ
LQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQL
AEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETM
PSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGA
QPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLI
GSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLG
VRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVT
VPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIG
LWLHDGLRL