Protein Info for Rv3717 in Mycobacterium tuberculosis H37Rv
Annotation: Conserved hypothetical protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to PEPAM_MYCTU: N-acetylmuramoyl-L-alanine amidase Rv3717 (Rv3717) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG orthology group: K01448, N-acetylmuramoyl-L-alanine amidase [EC: 3.5.1.28] (inferred from 100% identity to mbo:Mb3744)Predicted SEED Role
"N-acetylmuramoyl-L-alanine amidase"
MetaCyc Pathways
- peptidoglycan recycling I (8/14 steps found)
- peptidoglycan recycling II (2/10 steps found)
Isozymes
Compare fitness of predicted isozymes for: 3.5.1.28
Use Curated BLAST to search for 3.5.1.28
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (241 amino acids)
>Rv3717 Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv) MIVGVLVAAATPIISSASATPANIAGMVVFIDPGHNGANDASIGRQVPTGRGGTKNCQAS GTSTNSGYPEHTFTWETGLRLRAALNALGVRTALSRGNDNALGPCVDERANMANALRPNA IVSLHADGGPASGRGFHVNYSAPPLNAIQAGPSVQFARIMRDQLQASGIPKANYIGQDGL YGRSDLAGLNLAQYPSILVELGNMKNPADSALMESAEGRQKYANALVRGVAGFLATQGQA R