Protein Info for Rv3703c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 425 TIGR03440: ergothioneine biosynthesis protein EgtB" amino acids 8 to 422 (415 residues), 429.8 bits, see alignment E=7.4e-133 PF12867: DinB_2" amino acids 11 to 137 (127 residues), 43.6 bits, see alignment E=3.9e-15 PF03781: FGE-sulfatase" amino acids 166 to 423 (258 residues), 228.7 bits, see alignment E=1e-71

Best Hits

Swiss-Prot: 100% identical to EGTB_MYCTU: Hercynine oxygenase (egtB) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtc:MT3806)

MetaCyc: 77% identical to hercynine oxygenase (Mycolicibacterium smegmatis)
RXN-14430 [EC: 1.14.99.50]

Predicted SEED Role

"Putative methyltransferase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.99.50

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (425 amino acids)

>Rv3703c Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
VTSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGD
PGQPGLLPPAVEGLYDAFEHSRASRVELPLLSPARARSYCATVRSAALDALAALPEDGDS
FVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGRPRMAGTSVLVAGGPFVLGVD
AADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRA
GLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACA
WDPATGSRRRYPWGTEEPTDTYANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTS
PLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAILRPSFRNWDHPYRRQIFAGVR
LAWDI