Protein Info for Rv3617 in Mycobacterium tuberculosis H37Rv

Annotation: Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 PF00561: Abhydrolase_1" amino acids 27 to 130 (104 residues), 90.8 bits, see alignment E=1.7e-29 PF12146: Hydrolase_4" amino acids 28 to 156 (129 residues), 50.1 bits, see alignment E=3.7e-17 PF12697: Abhydrolase_6" amino acids 29 to 311 (283 residues), 76.2 bits, see alignment E=8.9e-25

Best Hits

Swiss-Prot: 100% identical to EPHA_MYCTU: Epoxide hydrolase A (ephA) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtb:TBMG_03654)

Predicted SEED Role

"Epoxide hydrolase (EC 3.3.2.9)" (EC 3.3.2.9)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.3.2.9

Use Curated BLAST to search for 3.3.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (322 amino acids)

>Rv3617 Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) (Mycobacterium tuberculosis H37Rv)
MGAPTERLVDTNGVRLRVVEAGEPGAPVVILAHGFPELAYSWRHQIPALADAGYHVLAPD
QRGYGGSSRPEAIEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADRV
AAVAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPGIADAELNGDPARTMRRMIGG
LRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQEELDHYIGEFTRTGFTGGLNWYR
NFDRNWETTADLAGKTISVPSLFIAGTADPVLTFTRTDRAAEVISGPYREVLIDGAGHWL
QQERPGEVTAALLEFLTGLELR