Protein Info for Rv3595c in Mycobacterium tuberculosis H37Rv

Annotation: PE-PGRS family protein PE_PGRS59

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details PF00934: PE" amino acids 4 to 94 (91 residues), 122.1 bits, see alignment E=9.5e-40 PF21526: PGRS" amino acids 116 to 185 (70 residues), 54.7 bits, see alignment E=1.1e-18

Best Hits

Swiss-Prot: 53% identical to PG20_MYCTO: Uncharacterized PE-PGRS family protein PE_PGRS20 (PE_PGRS20) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_13628)

Predicted SEED Role

"PE_PGRS family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (439 amino acids)

>Rv3595c PE-PGRS family protein PE_PGRS59 (Mycobacterium tuberculosis H37Rv)
MSFVIAVPEFLSAAATDLANLGSTISAANAAASIPTTGVLAAGADDVSAAIAALFGAHAQ
AYQTISAQAATFHAQFVQTLSAGAGAYANAEAANVQQSLLNAINAPTQALLGRPLIGDGA
DGTAPGQNGGAGGLLYGNGGNGAAGVNAGIAGGSGGAAGLIGNGGSGGAGGAGAAGGSGG
QGGLLYGNGGAGGNGGAATIPGGNGGAGGAGGNAWLFGNGGAGGLGAAGAAGAAGVNPLT
VPAGQGSMGNNGEPGGPGQPGTEFGQTGGTGGTGGTGLSVGGTGGTGGTGGTGGAGGSGG
RGGLLVGDGGAGGIGGTGGEGGIGARGGTGGQGGMGGAGQPGVGGDAGDGGNGGIGGDGG
AGGDGGAGGAGGAGGLFGVSGSSGLGGAAGSGGNGGGGGEPGVAGSPGVGPAGRGGDGNL
GQFGPEGAPGQPGQPGQPG