Protein Info for Rv3592 in Mycobacterium tuberculosis H37Rv

Annotation: Possible heme degrading protein MhuD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to MHUD_MYCTO: Heme oxygenase (mycobilin-producing) (mhuD) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K07145, (no description) (inferred from 100% identity to mtf:TBFG_13625)

MetaCyc: 100% identical to heme oxygenase (mycobilin-producing) monomer (Mycobacterium tuberculosis H37Rv)
RXN-18346 [EC: 1.14.99.57]; 1.14.99.57 [EC: 1.14.99.57]

Predicted SEED Role

"Antibiotic biosynthesis monooxygenase"

MetaCyc Pathways

heme degradation VII (2/2 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.99.57

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (105 amino acids)

>Rv3592 Possible heme degrading protein MhuD (Mycobacterium tuberculosis H37Rv)
MPVVKINAIEVPAGAGPELEKRFAHRAHAVENSPGFLGFQLLRPVKGEERYFVVTHWESD
EAFQAWANGPAIAAHAGHRANPVATGASLLEFEVVLDVGGTGKTA