Protein Info for Rv3573c in Mycobacterium tuberculosis H37Rv
Annotation: Probable acyl-CoA dehydrogenase FadE34
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to CHSE3_MYCTU: Acyl-CoA dehydrogenase FadE34 (fadE34) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_13606)MetaCyc: 100% identical to 3-oxocholest-4-en-26-oyl-CoA dehydrogenase monomer (Mycobacterium tuberculosis H37Rv)
1.3.99.-
Predicted SEED Role
"Acyl-CoA dehydrogenase (EC 1.3.8.1), Mycobacterial subgroup FadE34" (EC 1.3.8.1)
MetaCyc Pathways
- superpathway of cholesterol degradation I (cholesterol oxidase) (34/42 steps found)
- superpathway of cholesterol degradation II (cholesterol dehydrogenase) (36/47 steps found)
- oleate β-oxidation (27/35 steps found)
- superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
- β-alanine biosynthesis II (5/6 steps found)
- cholesterol degradation to androstenedione I (cholesterol oxidase) (12/17 steps found)
- valproate β-oxidation (6/9 steps found)
- cholesterol degradation to androstenedione II (cholesterol dehydrogenase) (14/22 steps found)
- sitosterol degradation to androstenedione (8/18 steps found)
- cholesterol degradation to androstenedione III (anaerobic) (10/22 steps found)
- superpathway of cholesterol degradation III (oxidase) (23/49 steps found)
Isozymes
Compare fitness of predicted isozymes for: 1.3.8.1
Use Curated BLAST to search for 1.3.8.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (711 amino acids)
>Rv3573c Probable acyl-CoA dehydrogenase FadE34 (Mycobacterium tuberculosis H37Rv) VVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRPVFAGLAGLGL FGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVATLVVSDPKLRSALASGERF AGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADGNWLLVDTACDEVVVEPLRAT DFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFG KPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAGVRRRLGVDLA EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPAPYGRGASPAEQLLIDQELAA AKVERPDLVIGWWAAPTILEHGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTK AVRADGGWLLTGQKVWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLR EITGDSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNPMEELLK VLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQAL AEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR