Protein Info for Rv3535c in Mycobacterium tuberculosis H37Rv

Annotation: Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating])

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03215: acetaldehyde dehydrogenase (acetylating)
  • amino acids 4 to 297 (294 residues), 455.9 bits, E=2.7e-141
• PF01118: Semialdhyde_dh
  • amino acids 6 to 117 (112 residues), 36.1 bits, E=7.8e-13
• PF09290: AcetDehyd-dimer
  • amino acids 127 to 272 (146 residues), 205.6 bits, E=3.4e-65

Best Hits

Swiss-Prot: 100% identical to ACDH_MYCTO: Acetaldehyde dehydrogenase (mhpF) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K04073, acetaldehyde dehydrogenase [EC: 1.2.1.10] (inferred from 100% identity to mtb:TBMG_03575)

MetaCyc: 100% identical to propanal dehydrogenase (Mycobacterium tuberculosis H37Rv)
RXN-12736 [EC: 1.2.1.87]

Predicted SEED Role

"Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol" in subsystem Biphenyl Degradation or Central meta-cleavage pathway of aromatic compound degradation (EC 1.2.1.10)

MetaCyc Pathways

• androstenedione degradation I (aerobic) (22/25 steps found)
• superpathway of cholesterol degradation I (cholesterol oxidase) (34/42 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (16/19 steps found)
• superpathway of cholesterol degradation II (cholesterol dehydrogenase) (36/47 steps found)
• superpathway of testosterone and androsterone degradation (22/28 steps found)
• mixed acid fermentation (13/16 steps found)
• superpathway of purine deoxyribonucleosides degradation (6/7 steps found)
• 2-deoxy-D-ribose degradation I (3/3 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (5/6 steps found)
• ethanol degradation I (2/2 steps found)
• (S)-propane-1,2-diol degradation (4/5 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• ethanolamine utilization (4/5 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• heterolactic fermentation (13/18 steps found)
• 2-deoxy-α-D-ribose 1-phosphate degradation (2/3 steps found)
• 2-hydroxypenta-2,4-dienoate degradation (2/3 steps found)
• pyruvate fermentation to ethanol I (2/3 steps found)
• pyruvate fermentation to ethanol III (2/3 steps found)
• L-threonine degradation IV (1/2 steps found)
• superpathway of L-threonine metabolism (12/18 steps found)
• 2-aminoethylphosphonate degradation I (1/3 steps found)
• sulfoacetaldehyde degradation IV (1/3 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (5/9 steps found)
• catechol degradation I (meta-cleavage pathway) (2/5 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (3/8 steps found)
• catechol degradation II (meta-cleavage pathway) (2/7 steps found)
• toluene degradation I (aerobic) (via o-cresol) (2/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (2/7 steps found)
• triethylamine degradation (1/6 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• p-cumate degradation (2/8 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• meta cleavage pathway of aromatic compounds (2/10 steps found)
• L-tryptophan degradation IX (3/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (3/12 steps found)
• naphthalene degradation to acetyl-CoA (3/12 steps found)
• p-cymene degradation (2/11 steps found)
• toluene degradation IV (aerobic) (via catechol) (2/13 steps found)
• mandelate degradation to acetyl-CoA (4/18 steps found)
• superpathway of aerobic toluene degradation (4/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (7/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (6/42 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.10 or 1.2.1.87

Protein Sequence (303 amino acids)

>Rv3535c Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]) (Mycobacterium tuberculosis H37Rv)
MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGLARAAKLGLETTHEGVD
WLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAAVGPAVIPPANLREHLDAP
NVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAGPGTRANIDEFTKTTARGVQT
IGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIAASIHDVVKEVQTYVPGYRLL
NEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETLVVG
GAR