Protein Info for Rv3432c in Mycobacterium tuberculosis H37Rv

Annotation: Probable glutamate decarboxylase GadB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01788: glutamate decarboxylase
  • amino acids 15 to 444 (430 residues), 696.8 bits, E=4.8e-214
• PF00282: Pyridoxal_deC
  • amino acids 41 to 380 (340 residues), 232.4 bits, E=3.6e-73

Best Hits

KEGG orthology group: K01580, glutamate decarboxylase [EC: 4.1.1.15] (inferred from 100% identity to mtb:TBMG_03480)

Predicted SEED Role

No annotation

MetaCyc Pathways

• L-glutamate degradation IX (via 4-aminobutanoate) (1/1 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Taurine and hypotaurine metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.15

Protein Sequence (460 amino acids)

>Rv3432c Probable glutamate decarboxylase GadB (Mycobacterium tuberculosis H37Rv)
VSRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRFIHDELMLDGSSRLNLA
TFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVADLFHAEGLRDHDPTSA
TGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRY
LPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAGGGVDVP
VHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGVGFVVWRGPEHLPEDL
VFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGYTKVMQALSHTARWLGDQLRE
VDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIV
VREGLSADLARALHDDAVTALAALDKVKPGGHFDAQHFAH