Protein Info for Rv3383c in Mycobacterium tuberculosis H37Rv

Annotation: Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00348: polyprenyl_synt
  • amino acids 66 to 302 (237 residues), 206.5 bits, E=2e-65

Best Hits

KEGG orthology group: K13787, geranylgeranyl diphosphate synthase, type I [EC: 2.5.1.1 2.5.1.10 2.5.1.29] (inferred from 100% identity to mtf:TBFG_13417)

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (33/33 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (12/12 steps found)
• taxadiene biosynthesis (engineered) (12/13 steps found)
• mono-trans, poly-cis decaprenyl phosphate biosynthesis (5/5 steps found)
• trans, trans-farnesyl diphosphate biosynthesis (2/2 steps found)
• polyisoprenoid biosynthesis (E. coli) (4/5 steps found)
• geranyl diphosphate biosynthesis (1/1 steps found)
• geranylgeranyl diphosphate biosynthesis (1/1 steps found)
• all-trans-farnesol biosynthesis (3/4 steps found)
• (3R)-linalool biosynthesis (1/2 steps found)
• (3S)-linalool biosynthesis (1/2 steps found)
• linalool biosynthesis I (1/2 steps found)
• methyl phomopsenoate biosynthesis (2/4 steps found)
• ophiobolin F biosynthesis (1/3 steps found)
• plaunotol biosynthesis (1/3 steps found)
• superpathway of linalool biosynthesis (1/3 steps found)
• bisabolene biosynthesis (engineered) (3/6 steps found)
• ipsdienol biosynthesis (1/4 steps found)
• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (5/10 steps found)
• superpathway of chorismate metabolism (40/59 steps found)
• stellatic acid biosynthesis (3/8 steps found)
• paspaline biosynthesis (1/6 steps found)
• superpathway of phylloquinol biosynthesis (7/15 steps found)
• brassicicene C biosynthesis (1/7 steps found)
• fusicoccin A biosynthesis (1/8 steps found)
• viridicatumtoxin biosynthesis (1/9 steps found)
• superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (3/12 steps found)
• superpathway of ergosterol biosynthesis II (13/26 steps found)
• superpathway of ergosterol biosynthesis I (6/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (23/56 steps found)
• superpathway of cholesterol biosynthesis (6/38 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.1, 2.5.1.10, 2.5.1.29

Use Curated BLAST to search for 2.5.1.1 or 2.5.1.10 or 2.5.1.29

Protein Sequence (350 amino acids)

>Rv3383c Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) (Mycobacterium tuberculosis H37Rv)
MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMAGYHLGWWNAD
RSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVHNFTLLHDDVMDGDATRRG
RPTVWSVWGVGVAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIGQFEDCL
LEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVD
DLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVER
ATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC