Protein Info for Rv3358 in Mycobacterium tuberculosis H37Rv

Annotation: Toxin RelK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 85 TIGR02116: addiction module toxin, Txe/YoeB family" amino acids 6 to 85 (80 residues), 124.7 bits, see alignment E=6.4e-41 PF06769: YoeB_toxin" amino acids 6 to 85 (80 residues), 135 bits, see alignment E=3.7e-44

Best Hits

Swiss-Prot: 99% identical to RELK_MYCTU: Toxin RelK (relK) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 99% identity to mtb:TBMG_03409)

MetaCyc: 49% identical to ribosome-dependent mRNA interferase toxin YoeB (Escherichia coli K-12 substr. MG1655)
RXN0-4701

Predicted SEED Role

"YoeB toxin protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (85 amino acids)

>Rv3358 Toxin RelK (Mycobacterium tuberculosis H37Rv)
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRR
IDDEHRLVYRAGDDEVTMLKARYHY