Protein Info for Rv3343c in Mycobacterium tuberculosis H37Rv

Annotation: PPE family protein PPE54

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2400 2523 PF00823: PPE" amino acids 3 to 165 (163 residues), 210.2 bits, see alignment 2.1e-66 PF01469: Pentapeptide_2" amino acids 187 to 220 (34 residues), 30.5 bits, see alignment (E = 2.8e-11) amino acids 254 to 292 (39 residues), 35.7 bits, see alignment (E = 6.5e-13) amino acids 297 to 335 (39 residues), 30.7 bits, see alignment (E = 2.3e-11) amino acids 337 to 374 (38 residues), 35.6 bits, see alignment (E = 7.1e-13) amino acids 376 to 415 (40 residues), 40.4 bits, see alignment (E = 2.1e-14) amino acids 750 to 787 (38 residues), 32.6 bits, see alignment (E = 5.9e-12) amino acids 792 to 830 (39 residues), 33.8 bits, see alignment (E = 2.6e-12) amino acids 802 to 840 (39 residues), 37.9 bits, see alignment (E = 1.3e-13) amino acids 1439 to 1477 (39 residues), 35.7 bits, see alignment (E = 6.5e-13) amino acids 1482 to 1520 (39 residues), 30.7 bits, see alignment (E = 2.3e-11) amino acids 1522 to 1559 (38 residues), 35.5 bits, see alignment (E = 7.4e-13) amino acids 1561 to 1600 (40 residues), 40.4 bits, see alignment (E = 2.1e-14) amino acids 2015 to 2053 (39 residues), 35.7 bits, see alignment (E = 6.5e-13) amino acids 2058 to 2096 (39 residues), 30.7 bits, see alignment (E = 2.3e-11) amino acids 2098 to 2135 (38 residues), 35.5 bits, see alignment (E = 7.4e-13) amino acids 2137 to 2176 (40 residues), 40.4 bits, see alignment (E = 2.1e-14)

Best Hits

Predicted SEED Role

"(MTV016.43c), len: 2523. Member of PPE-family of M. tuberculosis proteins, Gly-, Asn-rich MPTR subgroup. Most similar to MTV004_5 (3716 aa). FASTA scores: gp|AL0091|MTV004_5 Mycobacterium tuberculosis sequence (3716 aa)opt: 4672 z-score: 3736.8 E(): 0; 44.2% identity in 3174 aaoverlap. Also similar to MTV004_3, MTCY63_9, MTY13E10_17,MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23, MTV014_3, MTCY63_10 etc. TBparse score is 0.923"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2523 amino acids)

>Rv3343c PPE family protein PPE54 (Mycobacterium tuberculosis H37Rv)
MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAAFGSVTSGLVGGIWQGP
SSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALAETVDPFVIAANRSRLVSL
ALSNLFGQNTPAIAAAEFDYELMWAQDVAAMLGYHTGASAAAEALAPFGSPLASLAAAAE
PAKSLAVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYNVGGGNIGGNNVGLGNVGWGNFG
LGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGG
FNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGV
VNAGSYNTGSFNAGEANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGV
LWRGDYQGLLGFSSGANVLPVIPLSLDINGGVGAITIEPIHILPDIPININETLYLGPLV
VPPINVPAISLGVGIPNISIGPIKINPITLWPAQNFNQTITLAWPVSSITIPQIQQVALS
PSPIPTTLIGPIHINTGFSIPVTFSYSTPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFT
IPGFSIPEQPLPLAINVIGHINALSTPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGF
GNSTTAPSSGFFNTGAGGVSGFGNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGI
GNVGTQLSGMLSGGALGGNNFGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGN
IGIGLSGDNLTGFGGFNSGSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGN
NINVLAPFTPGTLFTISEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPE
ITIPAIPIHVTGTVGLEGFHVNPAFVLFGQTAMAEITADPVVLPDPFITIDHYGPPLGPP
GAKFPSGSFYLSISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQT
PVTVNLTGGLDSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTL
SIGPFPFRWDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALN
PLLTVTGNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQI
TNIQTQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLN
FSFGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIIT
EPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGPNVGLSNLG
GGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLMGLGN
IGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGT
GNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQ
ANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYR
PAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPSIPIPQIDLAATT
VSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTPIGLTPLALSQIVIG
ASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFPGGLTIPAMNPLSINLS
GGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFGNTTGAPSSGFFNSGAGGV
SGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLNFGSGMSGLFNTSVLGLGAPA
LVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGLGNVGLGNVGDFNLGAGNVGGFNV
GGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFA
NTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTG
IGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTG
VANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYTSTIIPEFTVANIHASGGAGPIIVP
SIQFPAIPLDLSATGHIGGFTIPPVSISPITVRIDPVFDLGPITVQDITIPALGLDPATG
VTVGPIFSSGSIIDPFSLTLLGFINVNVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIP
GFHIPVDPIHVELPLSVTIGPFVSPEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVL
DVNALLGPINAGLVIPPVPGFGNTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISD
PLLGSASGFANFGTQLSGILNRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTG
TGP