Protein Info for Rv3329 in Mycobacterium tuberculosis H37Rv

Annotation: Probable aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 12 to 426 (415 residues), 300.1 bits, E=1.1e-93

Best Hits

Swiss-Prot: 100% identical to Y3329_MYCTU: Probable aminotransferase Rv3329 (Rv3329) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbo:Mb3362)

MetaCyc: 37% identical to taurine:pyruvate aminotransferase subunit (Bilophila wadsworthia RZATAU)
Taurine--pyruvate aminotransferase. [EC: 2.6.1.77]

Predicted SEED Role

"Omega-amino acid--pyruvate aminotransferase (EC 2.6.1.18)" in subsystem Pyruvate Alanine Serine Interconversions (EC 2.6.1.18)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
• β-alanine biosynthesis II (5/6 steps found)
• β-alanine degradation II (2/2 steps found)
• taurine degradation I (1/1 steps found)
• hypotaurine degradation (2/3 steps found)
• superpathway of taurine degradation (3/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Propanoate metabolism
• Taurine and hypotaurine metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.18 or 2.6.1.77

Protein Sequence (438 amino acids)

>Rv3329 Probable aminotransferase (Mycobacterium tuberculosis H37Rv)
LHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGYGRAELAEAAARQAGT
LGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAVETAWKVAKQYFKLTGKPG
KQKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFRVPNTNFYRAPLHTDLKEFGR
WAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVI
CAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDGETMFAHGYT
FGGHPVSAAVGLANLDIFEREGLSDHVKRNSPALRATLEKLYDLPIVGDIRGEGYFFGIE
LVKDQATKQTFTDDERARLLGQVSAALFEAGLYCRTDDRGDPVVQVAPPLISGQPEFDTI
ETILRSVLTDTGRKYLHL