Protein Info for Rv3296 in Mycobacterium tuberculosis H37Rv

Annotation: Probable ATP-dependent helicase Lhr (large helicase-related protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1513 transmembrane" amino acids 1488 to 1505 (18 residues), see Phobius details PF00270: DEAD" amino acids 28 to 212 (185 residues), 106.6 bits, see alignment E=2.3e-34 PF04851: ResIII" amino acids 34 to 211 (178 residues), 24.4 bits, see alignment E=4.9e-09 PF00271: Helicase_C" amino acids 334 to 399 (66 residues), 50.1 bits, see alignment (E = 6.3e-17) PF08494: DEAD_assoc" amino acids 659 to 851 (193 residues), 202.6 bits, see alignment E=1.1e-63

Best Hits

Predicted SEED Role

"Probable ATP-dependent helicase lhr (EC 3.6.1.-)" (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1513 amino acids)

>Rv3296 Probable ATP-dependent helicase Lhr (large helicase-related protein) (Mycobacterium tuberculosis H37Rv)
VRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNTLVIAPTGSGKTLAAFL
WALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPLAGLTRLAERQGLPAPQIR
VGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAAT
KRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELARFLSGQSPTTIVAPPAAKTVEL
SVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTIVFANSRRLAERLTARLNEIHAARC
GIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKA
VVATSSLELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTDLLG
CAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDTVRRAAPFATLPRS
LFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGLFAVY
LATERPSRVGELDEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRG
DDAGRPAELGAALGALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVP
TDSTLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTASDNGIVV
RLPDTVSAGEDSPPGAELFVFDADEIDPIVTTEVAGSALFASRFRESAARALLLPRRHPG
RRSPLWQQRQRAARLLEVARKYPDFPIVLETVRECLQDVYDVPILVELMARIAQRRVRVA
EAETAKPSPFAASLLFGYVGAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDP
DVIAATSRQLQHLAADRVARDAEGVADLLRLLGPLTEDEIAARAGAPEVSGWLDGLRAAK
RALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPLGELLGRYARTHTPF
TTAAAAARFGLGLRVTADVLGRLASDGRLVRGEFVAAAKGSAGGEQWCDAEVLRILRRRS
LAALRAQAEPVSTAAYGRFLPAWQHVSAGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAP
RIRDYSPAMLDELLASGDVTWSGAGSISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRA
ILASLGTGGAYFFRQLTHDGLTEAELKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRA
APAHGGHRPPRLSRYRLTHAQARNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGV
LTKDAVAAEGVAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYLDG
VDPEQPDYHAVVLAAADPANPYGAALPWPASSADGTARPGRKAGALVVLVDGELAWFLER
GGRSLLTFTDDPEANHAAAIGLADLVTAGRVASILVERADGMPVLQPGGRASAALTALLA
AGFVRTPRGLRRR