Protein Info for Rv3270 in Mycobacterium tuberculosis H37Rv

Annotation: Probable metal cation-transporting P-type ATPase C CtpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 718 transmembrane" amino acids 96 to 115 (20 residues), see Phobius details amino acids 126 to 146 (21 residues), see Phobius details amino acids 158 to 186 (29 residues), see Phobius details amino acids 334 to 351 (18 residues), see Phobius details amino acids 357 to 381 (25 residues), see Phobius details amino acids 673 to 699 (27 residues), see Phobius details TIGR01511: copper-translocating P-type ATPase" amino acids 138 to 711 (574 residues), 408.9 bits, see alignment E=7.9e-126 TIGR01525: heavy metal translocating P-type ATPase" amino acids 157 to 711 (555 residues), 558.3 bits, see alignment E=4.6e-171 PF00122: E1-E2_ATPase" amino acids 227 to 386 (160 residues), 144.1 bits, see alignment E=3.6e-46 TIGR01494: HAD ATPase, P-type, family IC" amino acids 228 to 689 (462 residues), 238.2 bits, see alignment E=2.8e-74 PF00702: Hydrolase" amino acids 402 to 622 (221 residues), 138.6 bits, see alignment E=3.5e-44

Best Hits

Swiss-Prot: 100% identical to CTPC_MYCTO: Manganese-exporting P-type ATPase (ctpC) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K12950, cation-transporting P-type ATPase C [EC: 3.6.3.-] (inferred from 100% identity to mtf:TBFG_13299)

Predicted SEED Role

"Probable cation-transporting P-type ATPase C (EC 3.6.3.-) (Metal-transporting ATPase Mta72); FUPA32 P-type ATPase" (EC 3.6.3.-)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (718 amino acids)

>Rv3270 Probable metal cation-transporting P-type ATPase C CtpC (Mycobacterium tuberculosis H37Rv)
MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVHAYPRTGSVVVWYSPRR
ADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIGGVALALLGVRRYVFARPP
LLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAATVASLILRENVVALTVL
WLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTDPSAGSDAATEIQVPIDTVQIGD
EVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVVGTRVHAGSVVVRGRVVVRAHA
VGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRRFVPTSFIVSAIALLITGDVRRAMTML
LIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQAGRVDAIVFDKTGTLTVGRPVV
TNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRSTEERRISIPPHEECEVLVGLGMR
TWADGRTLLLGSPSLLRAEKVRVSKKASEWVDKLRRQAETPLLLAVDGTLVGLISLRDEV
RPEAAQVLTKLRANGIRRIVMLTGDHPEIAQVVADELGIDEWRAEVMPEDKLAAVRELQD
DGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVAVETADVALANDDLHRLLDVGDLGER
AVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAAILHNASSVAVVANSSRLIRYRLDR