Protein Info for Rv3245c in Mycobacterium tuberculosis H37Rv
Annotation: Two component sensory transduction histidine kinase MtrB
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to MTRB_MYCTU: Sensor histidine kinase MtrB (mtrB) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG orthology group: K07654, two-component system, OmpR family, sensor histidine kinase MtrB [EC: 2.7.13.3] (inferred from 100% identity to mtc:MT3343)Predicted SEED Role
"Sensor histidine kinase MtrB (EC 2.7.3.-)" (EC 2.7.3.-)
Isozymes
Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-
Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (567 amino acids)
>Rv3245c Two component sensory transduction histidine kinase MtrB (Mycobacterium tuberculosis H37Rv) MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFV LTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASG AGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQAAYQYATVQTEGFSGPAL IIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFT SDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHD AGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLPAEQVIAEVDARRVERILRNL IANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPMVRGHKVTTSPLPMKPIPQPVLQP VAQPNPQPMPPEYKERQRPREHAEWSG