Protein Info for Rv3200c in Mycobacterium tuberculosis H37Rv

Annotation: Possible transmembrane cation transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 355 transmembrane" amino acids 40 to 60 (21 residues), see Phobius details amino acids 74 to 91 (18 residues), see Phobius details amino acids 103 to 127 (25 residues), see Phobius details PF07885: Ion_trans_2" amino acids 48 to 129 (82 residues), 53.5 bits, see alignment E=1.9e-18 PF02254: TrkA_N" amino acids 150 to 266 (117 residues), 95.9 bits, see alignment E=2.2e-31

Best Hits

KEGG orthology group: None (inferred from 99% identity to mbb:BCG_3225c)

Predicted SEED Role

"Potassium channel protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (355 amino acids)

>Rv3200c Possible transmembrane cation transporter (Mycobacterium tuberculosis H37Rv)
VAGSWRRLRGLNEKLTAQPGYALVGVLRIPQRRASPARVISRRVVVAVVALLLTAGIVYV
DRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFARAINIFVITPLRIAFLILL
VGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKTAVAAMVSDELVPGEIVVVDT
DSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSIIVATSRDDTAVLVTLTAREIAPK
AKIVASIREAENQHLLRQSGADTVVVSSETAGRLLGIATTTPSVVEMIEDLLTPEAGLAV
AEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIGAPEVDAIEASDRLLYIRQVGR