Protein Info for Rv3140 in Mycobacterium tuberculosis H37Rv

Annotation: Probable acyl-CoA dehydrogenase FadE23

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02770: Acyl-CoA_dh_M
  • amino acids 130 to 224 (95 residues), 86.9 bits, E=1.3e-28
• PF00441: Acyl-CoA_dh_1
  • amino acids 241 to 393 (153 residues), 113.6 bits, E=1.5e-36
• PF08028: Acyl-CoA_dh_2
  • amino acids 257 to 381 (125 residues), 45.7 bits, E=1.2e-15

Best Hits

KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 100% identity to mbo:Mb3164)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.1), Mycobacterial subgroup FadE23" (EC 1.3.8.1)

MetaCyc Pathways

• oleate β-oxidation (27/35 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
• β-alanine biosynthesis II (5/6 steps found)
• valproate β-oxidation (6/9 steps found)

KEGG Metabolic Maps

• Fatty acid metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.1, 1.3.99.3

Use Curated BLAST to search for 1.3.8.1 or 1.3.99.3

Protein Sequence (401 amino acids)

>Rv3140 Probable acyl-CoA dehydrogenase FadE23 (Mycobacterium tuberculosis H37Rv)
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNF
AGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQ
LERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
DKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEF
LRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSE
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK