Protein Info for Rv3050c in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein (probably AsnC-family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 transmembrane" amino acids 171 to 191 (21 residues), see Phobius details amino acids 206 to 228 (23 residues), see Phobius details PF00440: TetR_N" amino acids 35 to 80 (46 residues), 45.6 bits, see alignment 2.4e-16

Best Hits

KEGG orthology group: None (inferred from 100% identity to mbo:Mb3076c)

Predicted SEED Role

"Transcriptional regulator, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (246 amino acids)

>Rv3050c Probable transcriptional regulatory protein (probably AsnC-family) (Mycobacterium tuberculosis H37Rv)
VVRIPRPHPSAKPGVKVDARSERWREHRKKVRNEIVDAAFRAIDRLGPELSVRQIAEEAG
TAKPKIYRHFTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVDQ
HPNVLRVFIQGRSAKQSEATVRTLNEGREITLAMAEMFNNELREMELNRAALELAAFAAF
GSAASATEWWLGPEPDSPRRMPREQFVAHLTTIMMGVIVGTAEALGIAVDPDQPIHDAVP
NNPAVR