Protein Info for Rv3000 in Mycobacterium tuberculosis H37Rv

Annotation: Possible conserved transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 transmembrane" amino acids 149 to 167 (19 residues), see Phobius details amino acids 173 to 198 (26 residues), see Phobius details PF00005: ABC_tran" amino acids 21 to 122 (102 residues), 54.4 bits, see alignment E=2.1e-18 PF03649: UPF0014" amino acids 112 to 203 (92 residues), 110.5 bits, see alignment E=8.8e-36

Best Hits

KEGG orthology group: K02069, putative ABC transport system permease protein (inferred from 100% identity to mra:MRA_3029)

Predicted SEED Role

"YbbM seven transmembrane helix protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (219 amino acids)

>Rv3000 Possible conserved transmembrane protein (Mycobacterium tuberculosis H37Rv)
MAVHGFLLERVSVVRDEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTSG
KVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEGRVTELLARLCL
GQSAREAFLPHQRSALRTALIPAIDSTKVVGLISLPGAMSGLILAGVDPLTAIRYQIVVM
YLLLAATAVAALTCARLAERALFDRAHRLVSLPAATRRA