Protein Info for Rv2948c in Mycobacterium tuberculosis H37Rv

Annotation: P-hydroxybenzoyl-AMP ligase FadD22

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 705 PF00501: AMP-binding" amino acids 17 to 354 (338 residues), 212.8 bits, see alignment E=1.1e-66 PF13193: AMP-binding_C" amino acids 402 to 480 (79 residues), 44 bits, see alignment E=5.4e-15 PF00550: PP-binding" amino acids 549 to 615 (67 residues), 29.7 bits, see alignment E=9.6e-11

Best Hits

Swiss-Prot: 100% identical to FAA22_MYCBO: p-hydroxybenzoic acid--AMP ligase FadD22 (fadD22) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K12424, fatty acid CoA ligase FadD22 (inferred from 100% identity to mtc:MT3021)

MetaCyc: 100% identical to 4-hydroxybenzate adenylase (Mycobacterium tuberculosis variant bovis)
RXN-18535 [EC: 6.2.1.50]

Predicted SEED Role

No annotation

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.50

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (705 amino acids)

>Rv2948c P-hydroxybenzoyl-AMP ligase FadD22 (Mycobacterium tuberculosis H37Rv)
MRNGNLAGLLAEQASEAGWYDRPAFYAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLL
CLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDALRDRFQPSR
VAEAAELMSEAARVAPGGYEPMGGDALAYATYTSGTTGPPKAAIHRHADPLTFVDAMCRK
ALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAILSARFGPSVL
YGVPNFFARVIDSCSPDSFRSLRCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQ
TFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSP
VANEGWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVA
VRESTGASTLQAFLVATSGATIDGSVMRDLHRGLLNRLSAFKVPHRFAVVDRLPRTPNGK
LVRGALRKQSPTKPIWELSLTEPGSGVRAQRDDLSASNMTIAGGNDGGATLRERLVALRQ
ERQRLVVDAVCAEAAKMLGEPDPWSVDQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPET
VGWDYGSISGLAQYLEAELAGGHGRLKSAGPVNSGATGLWAIEEQLNKVEELVAVIADGE
KQRVADRLRALLGTIAGSEAGLGKLIQAASTPDEIFQLIDSELGK