Protein Info for Rv2946c in Mycobacterium tuberculosis H37Rv

Annotation: Probable polyketide synthase Pks1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1616 transmembrane" amino acids 1009 to 1028 (20 residues), see Phobius details PF00698: Acyl_transf_1" amino acids 86 to 395 (310 residues), 208.8 bits, see alignment E=8.1e-65 PF21089: PKS_DH_N" amino acids 445 to 545 (101 residues), 101.3 bits, see alignment 1.4e-32 PF14765: PS-DH" amino acids 567 to 719 (153 residues), 105.2 bits, see alignment E=1.6e-33 PF08240: ADH_N" amino acids 930 to 985 (56 residues), 29.3 bits, see alignment (E = 3.6e-10) PF00107: ADH_zinc_N" amino acids 1048 to 1140 (93 residues), 51 bits, see alignment 8e-17 PF13602: ADH_zinc_N_2" amino acids 1084 to 1215 (132 residues), 68.8 bits, see alignment E=5.2e-22 PF08659: KR" amino acids 1228 to 1407 (180 residues), 206 bits, see alignment E=2.5e-64 PF00106: adh_short" amino acids 1229 to 1389 (161 residues), 54.8 bits, see alignment E=4.9e-18 PF01370: Epimerase" amino acids 1230 to 1374 (145 residues), 23.7 bits, see alignment E=1.7e-08 PF13561: adh_short_C2" amino acids 1257 to 1388 (132 residues), 39 bits, see alignment E=3.9e-13 PF00550: PP-binding" amino acids 1524 to 1585 (62 residues), 56 bits, see alignment (E = 2.1e-18)

Best Hits

Swiss-Prot: 100% identical to PKS1_MYCTU: Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 (pks1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Predicted SEED Role

"Polyketide synthase Pks1"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1616 amino acids)

>Rv2946c Probable polyketide synthase Pks1 (Mycobacterium tuberculosis H37Rv)
VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL
AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD
RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA
AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES
VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG
LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ
SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR
RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN
GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV
SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP
AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR
LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA
AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA
GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM
ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES
AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL
GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV
FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG
FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI
RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA
FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS
RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL
DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA
NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL
FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL
AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK
TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA